| Tag | Content |
|---|
| CPLM ID | CPLM-024428 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sister chromatid cohesion protein PDS5 homolog A |
Protein Synonyms/Alias | |
Gene Name | Pds5a |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1145 | GVLGTVNKPLSATGR | acetylation | [1] | | 1210 | IISVTPVKSIDTVKN | acetylation | [1] | | 1289 | TKNDDLSKPVSKGRK | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity). |
Sequence Annotation | REPEAT 392 428 HEAT.
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 1145 1145 N6-acetyllysine (By similarity).
MOD_RES 1194 1194 Phosphoserine (By similarity).
MOD_RES 1207 1207 Phosphothreonine (By similarity).
MOD_RES 1210 1210 N6-acetyllysine (By similarity).
MOD_RES 1289 1289 N6-acetyllysine (By similarity).
MOD_RES 1304 1304 Phosphoserine (By similarity). |
Keyword | Acetylation; Cell cycle; Cell division; Complete proteome; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1333 AA |
Protein Sequence | MDFTQPKPAT ALCGVVSADG KIAYPPGVKE ITDKITTDEM IKRLKMVVKT FMDMDQDSED 60
EKQQYLPLAL HLASEFFLRN PNKDVRLLVA CCLADIFRIY APEAPYTSHD KLKDIFLFIT 120
RQLKGLEDTK SPQFNRYFYL LENLAWVKSY NICFELEDCN EIFIQLFRTL FSVINNSHNK 180
KVQMHMLDLM SSIIMEGDGV TQELLDSILI NLIPAHKNLN KQSFDLAKVL LKRTVQTIEA 240
CIANFFNQVL VLGRSSVSDL SEHVFDLIQE LFAIDPHLLL SVMPQLEFKL KSNDGEERLA 300
VVRLLAKLFG SKDSDLATQN RPLWQCFLGR FNDIHVPVRL ESVKFASHCL MNHPDLAKDL 360
TEYLKVRSHD PEEAIRHDVI VTIITAAKRD LALVNDQLLG FVRERTLDKR WRVRKEAMMG 420
LAQLYKKYCL HGEAGKEAAE KVSWIKDKLL HIYYQNSIDD KLLVEKIFAQ YLVPHNLETE 480
ERMKCLYYLY ASLDPNAVKA LNEMWKCQNM LRSHVRELLD LHKQPTSEAN CSAMFGKLMT 540
IAKNLPDPGK AQDFVKKFNQ VLGDDEKLRS QLELLISPTC SCKQADICVR EIARKLANPK 600
QPTNPFLEMV KFLLERIAPV HIDSEAISAL VKLMNKSIEG TADDEEEGVS PDSAIRSGLE 660
LLKVLSFTHP TSFHSAETYE SLLQCLRMED DKVAEAAIQI FRNTGHKIET DLPQIRSTLI 720
PILHQKAKRG TPHQAKQAVH CIHAIFSNKE VQLAQIFEPL SRSLNADVPE QLITPLVSLG 780
HISMLAPDQF ASPMKSVVAN FIVKDLLMND RSTGEKNGKL WSPDEEVSPE VLAKVQAIKL 840
LVRWLLGMKN NQSKSANSTL RLLSAMLVSE GDLTEQKRIS KSDMSRLRLA AGSAIMKLAQ 900
EPCYHEIITP EQFQLCALVI NDECYQVRQI FAQKLHKALV KLLLPLEYMA IFALCAKDPV 960
KERRAHARQC LLKNISIRRE YIKQNPMATE KLLSLLPEYV VPYMIHLLAH DPDFTRSQDV 1020
DQLRDIKECL WFMLEVLMTK NENNSHAFMK KMAENIKLTR DAQSPDEAKT NEKLYTVCDV 1080
ALCVINSKSA LCNADSPKDP VLPMKFFTQP EKDFSNDKSY ISEETRVLLL TGKPKPTGVL 1140
GTVNKPLSAT GRKPYVRSAG TETGSNINAS SELSPSAGNR SREQSSEASE TGVSENEENP 1200
VRIISVTPVK SIDTVKNKEI NSDQSTQGNI SSDRGKKRIV TAAGAENIQQ KPDEKADESG 1260
PPAPSKPRRG RRPKSESQGN ATKNDDLSKP VSKGRKRAAG SQESLEAGNA KAPKLQDGAK 1320
KAVPAERQID LQR 1333 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |