CPLM-001929

Genbank Nucleotide ID

Hemoglobin subunit alpha

Protein Synonyms/Alias

Alpha-globin; Hemoglobin alpha chain

Mus musculus (Mouse)

Position	Peptide	Type	References
8	MVLSGEDKSNIKAAW	acetylation	[1, 2]
8	MVLSGEDKSNIKAAW	succinylation	[2]
8	MVLSGEDKSNIKAAW	ubiquitination	[3]
12	GEDKSNIKAAWGKIG	acetylation	[2]
12	GEDKSNIKAAWGKIG	phosphoglycerylation	[4]
12	GEDKSNIKAAWGKIG	succinylation	[2]
12	GEDKSNIKAAWGKIG	ubiquitination	[3]
17	NIKAAWGKIGGHGAE	acetylation	[1, 2, 5, 6, 7, 8]
17	NIKAAWGKIGGHGAE	phosphoglycerylation	[4]
17	NIKAAWGKIGGHGAE	succinylation	[2]
17	NIKAAWGKIGGHGAE	ubiquitination	[3]
41	FASFPTTKTYFPHFD	acetylation	[1, 2]
41	FASFPTTKTYFPHFD	succinylation	[2]
41	FASFPTTKTYFPHFD	ubiquitination	[3]
57	SHGSAQVKGHGKKVA	phosphoglycerylation	[4]
57	SHGSAQVKGHGKKVA	ubiquitination	[3]
140	VSTVLTSKYR*****	acetylation	[1]
140	VSTVLTSKYR*****	ubiquitination	[3]

[1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
[2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
[3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[4] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
Moellering RE, Cravatt BF.
Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237]
[5] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647]
[6] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
Simon GM, Cheng J, Gordon JI.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
[7] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
[8] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]

Functional Description

Involved in oxygen transport from the lung to the various peripheral tissues.

METAL 59 59 Iron (heme distal ligand).
METAL 88 88 Iron (heme proximal ligand).
MOD_RES 17 17 N6-acetyllysine (By similarity).

3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport; Polymorphism; Reference proteome; Transport.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005833; C:hemoglobin complex; IEA:InterPro.
GO:0020037; F:heme binding; IEA:InterPro.
GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0019825; F:oxygen binding; IEA:InterPro.
GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW.
GO:0035634; P:response to stilbenoid; IEP:UniProtKB.

IPR000971; Globin.
IPR009050; Globin-like.
IPR012292; Globin_dom.
IPR002338; Haemoglobin_a.
IPR018331; Haemoglobin_alpha_chain.
IPR002339; Haemoglobin_pi.

PR00612; ALPHAHAEM.
PR00815; PIHAEM.