CPLM-014908

Genbank Nucleotide ID

Protein Synonyms/Alias

Cytokine-induced apoptosis inhibitor 1; Fe-S cluster assembly protein DRE2 homolog

Homo sapiens (Human)

Position	Peptide	Type	References
31	ALKGLVDKLQALTGN	ubiquitination	[1, 2, 3, 4, 5]
48	RVSVENIKQLLQSAH	ubiquitination	[1, 3, 4, 5]
96	PGGCLFLKEPVETAV	ubiquitination	[4]
225	LLDPEDLKKPDPASL	ubiquitination	[2, 6]
226	LDPEDLKKPDPASLR	ubiquitination	[6]
271	EQMSSQPKSACGNCY	ubiquitination	[4]
301	PAFKPGEKVLLSDSN	acetylation	[7]

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
[6] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
[7] Regulation of cellular metabolism by protein lysine acetylation.
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]

Functional Description

May be required for the maturation of extramitochondrial Fe/S proteins (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity).

MOD_RES 182 182 Phosphoserine.
MOD_RES 183 183 Phosphoserine.
MOD_RES 305 305 Phosphoserine.
MOD_RES 307 307 Phosphoserine.

3D-structure; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005730; C:nucleolus; IDA:UniProtKB.
GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0030097; P:hemopoiesis; IEA:Compara.
GO:0016226; P:iron-sulfur cluster assembly; IEA:HAMAP.
GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO:0044281; P:small molecule metabolic process; TAS:Reactome.

IPR007785; Anamorsin.