UniProt Accession

 LGUL_ECOLI; P0AC81; P77036; Q2MB62; Q59384 

Genbank Protein ID

 U57363; U00096; AP009048; D86931 

Genbank Nucleotide ID

 AAC27133.1; AAC74723.1; BAE76494.1; BAA13187.1 

Protein Name

 Lactoylglutathione lyase 

Protein Synonyms/Alias

 Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase 

Gene Name

 gloA 

Gene Synonyms/Alias

 b1651; JW1643 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
22	RSIDFYTKVLGMKLL	acetylation	[1]
27	YTKVLGMKLLRTSEN	acetylation	[1]
127	KIELIEEKDAGRGLG	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. 

Sequence Annotation

 METAL 5 5 Nickel.
 METAL 56 56 Nickel.
 METAL 74 74 Nickel.
 METAL 122 122 Nickel.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Lyase; Metal-binding; Nickel; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 135 AA 

Protein Sequence

Gene Ontology

 GO:0004462; F:lactoylglutathione lyase activity; IDA:EcoCyc.
 GO:0016151; F:nickel cation binding; IDA:EcoCyc.
 GO:0019243; P:methylglyoxal catabolic process to D-lactate; IMP:EcoCyc. 

Interpro

 IPR004360; Glyas_Fos-R_dOase_dom.
 IPR004361; Glyoxalase_1.
 IPR018146; Glyoxalase_1_CS. 

Pfam

 PF00903; Glyoxalase 

SMART

  

PROSITE

 PS00934; GLYOXALASE_I_1
 PS00935; GLYOXALASE_I_2 

PRINTS