| Tag | Content |
|---|
| CPLM ID | CPLM-022647 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1 |
Protein Synonyms/Alias | 3-hydroxyacyl-CoA dehydratase 1; HACD1; Protein-tyrosine phosphatase-like member A |
Gene Name | Ptpla |
Gene Synonyms/Alias | hacd1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 279 | HGEVIAEKDD***** | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis (By similarity). |
Sequence Annotation | ACT_SITE 203 203 By similarity.
ACT_SITE 210 210 By similarity.
CARBOHYD 236 236 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Developmental protein; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Lyase; Membrane; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 281 AA |
Protein Sequence | MGKGDWRQGR VEMPCAHVSR LHKTCVQVRV RVTMASSEED GTNGASEASD EKEAAGKRRR 60
LGLLATAWLT FYNIAMTAGW LVLAIAMVRF YMEKGTHRGL YKSIQKTLKF FQTFALLEVV 120
HCLIGIVPTS VLVTGVQVSS RIFMVWLITH SIKPIQNEES VVLFLVSWTV TEITRYSFYT 180
FSLLDHLPHF IKWARYNLFI ILYPVGVAGE LLTIYAALPY VKKSGMFSVR LPNKYNVSFD 240
YYYFLLITMA SYIPLFPQLY FHMLRQRRKV LHGEVIAEKD D 281 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016829; F:lyase activity; IEA:UniProtKB-KW. GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |