UniProt Accession

 MAAI_RAT; P57113; B0BNI1 

Genbank Protein ID

 FJ179410; CH473982; BC158833 

Genbank Nucleotide ID

 ACI32127.1; EDL81627.1; AAI58834.1 

Protein Name

 Maleylacetoacetate isomerase 

Protein Synonyms/Alias

 MAAI; GSTZ1-1; Glutathione S-transferase zeta 1 

Gene Name

 Gstz1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
95	LLPQDPQKRAIVRMI	acetylation	[1]
133	NQMPWAQKAITSGFN	acetylation	[1]
144	SGFNALEKILQSTAG	acetylation	[1]
177	VANAERFKVDLSPYP	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Probable bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7- chloro-4-nitrobenz-2-oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with t-butyl and cumene hydroperoxides (By similarity). Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. 

Sequence Annotation

 DOMAIN 4 87 GST N-terminal.
 DOMAIN 92 212 GST C-terminal.
 REGION 14 19 Glutathione binding (By similarity).
 REGION 71 72 Glutathione binding (By similarity).
 REGION 115 117 Glutathione binding (By similarity).
 BINDING 45 45 Glutathione (By similarity).
 BINDING 59 59 Glutathione; via amide nitrogen and
 BINDING 111 111 Glutathione (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Isomerase; Multifunctional enzyme; Phenylalanine catabolism; Reference proteome; Transferase; Tyrosine catabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 216 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004364; F:glutathione transferase activity; IEA:EC.
 GO:0016034; F:maleylacetoacetate isomerase activity; IEA:EC.
 GO:0006749; P:glutathione metabolic process; IEA:Compara.
 GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
 GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR004046; GST_C.
 IPR005955; Mal_ac_isom.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00043; GST_C 

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS