CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030306
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PCNX protein 
Protein Synonyms/Alias
 Pecanex-like protein 1 
Gene Name
 PCNX 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1142VKDPLPEKLRNSVSEubiquitination[1]
1205YVLPQVRKQLPWHCFubiquitination[2]
1218CFSHPLLKTLEYNQYubiquitination[2]
1863RGSIQNAKQALRNMIubiquitination[1, 2, 3, 4, 5, 6]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2230 AA 
Protein Sequence
MGSQTLQILR QGVWAALSGG WYYDPHQATF VNALHLYLWL FLLGLPFTLY MALPSTMIIV 60
AVYCPVIAAV FIVLKMVNYR LHRALDAGEV VDRTANEFTD QRTKAEQGNC STRRKDSNGP 120
SDPGGGIEMS EFIREATPPV GCSSRNSYAG LDPSNQIGSG SSRLGTAATI KGDTDTAKTS 180
DDISLSLGQS SSLCKEGSEE QDLAADRKLF RLVSNDSFIS IQPSLSSCGQ DLPRDFSDKV 240
NLPSHNHHHH VDQSLSSACD TEVASLVPLH SHSYRKDHRP RGVPRTSSSA VAFPDTSLND 300
FPLYQQRRGL DPVSELESSK PLSGSKESLV ENSGLSGEFQ LAGDLKINTS QPPTKSGKSK 360
PLKAEKSMDS LRSLSTRSSG STESYCSGTD RDTNSTVSSY KSEQTSSTHI ESILSEHEES 420
PKAGTKSGRK KECCAGPEEK NSCASDKRTS SEKIAMEAST NSGVHEAKDP TPSDEMHNQR 480
GLSTSASEEA NKNPHANEFT SQGDRPPGNT AENKEEKSDK SAVSVDSKVR KDVGGKQKEG 540
DVRPKSSSVI HRTASAHKSG RRRTGKKRAS SFDSSRHRDY VCFRGVSGTK PHSAIFCHDE 600
DSSDQSDLSR ASSVQSAHQF SSDSSSSTTS HSCQSPEGRY SALKTKHTHK ERGTDSEHTH 660
KAHLVPEGTS KKRATRRTSS TNSAKTRARV LSLDSGTVAC LNDSNRLMAP ESIKPLTTSK 720
SDLEAKEGEV LDELSLLGRA SQLETVTRSR NSLPNQVAFP EGEEQDAVSG GKFSSTLYET 780
GGCDMSLVNF EPAARRASNI CDTDSHVSSS TSVRFYPHDV IRLNRLLTID TDLLEQQDID 840
LSPDLAATYG PTEEAAQKVK HYYRFWILPQ LWIGINFDRL TLLALFDRNR EILENVLAVI 900
LAILVAFLGS ILLIQGFFRD IWVFQFCLVI ASCQYSLLKS VQPDSSSPRH GHNRIIAYSR 960
PVYFCICCGL IWLLDYGSRN LTATKFKLYG ITFTNPLVFI SARDLVIVFT LCFPIVFFIG 1020
LLPQVNTFVM YLCEQLDIHI FGGNATTSLL AALYSFICSI VAVALLYGLC YGALKDSWDG 1080
QHIPVLFSIF CGLLVAVSYH LSRQSSDPSV LFSLVQSKIF PKTEEKNPED PLSEVKDPLP 1140
EKLRNSVSER LQSDLVVCIV IGVLYFAIHV STVFTVLQPA LKYVLYTLVG FVGFVTHYVL 1200
PQVRKQLPWH CFSHPLLKTL EYNQYEVRNA ATMMWFEKLH VWLLFVEKNI IYPLIVLNEL 1260
SSSAETIASP KKLNTELGAL MITVAGLKLL RSSFSSPTYQ YVTVIFTVLF FKFDYEAFSE 1320
TMLLDLFFMS ILFNKLWELL YKLQFVYTYI APWQITWGSA FHAFAQPFAV PHSAMLFIQA 1380
AVSAFFSTPL NPFLGSAIFI TSYVRPVKFW ERDYNTKRVD HSNTRLASQL DRNPGSDDNN 1440
LNSIFYEHLT RSLQHSLCGD LLLGRWGNYS TGDCFILASD YLNALVHLIE IGNGLVTFQL 1500
RGLEFRGTYC QQREVEAITE GVEEDEGFCC CEPGHIPHML SFNAAFSQRW LAWEVIVTKY 1560
ILEGYSITDN SAASMLQVFD LRKVLTTYYV KGIIYYVTTS SKLEEWLANE TMQEGLRLCA 1620
DRNYVDVDPT FNPNIDEDYD HRLAGISRES FCVIYLNWIE YCSSRRAKPV DVDKDSSLVT 1680
LCYGLCVLGR RALGTASHHM SSNLESFLYG LHALFKGDFR ISSIRDEWIF ADMELLRKVV 1740
VPGIRMSIKL HQDHFTSPDE YDDPTVLYEA IVSHEKNLVI AHEGDPAWRS AVLANSPSLL 1800
ALRHVMDDGT NEYKIIMLNR RYLSFRVIKV NKECVRGLWA GQQQELVFLR NRNPERGSIQ 1860
NAKQALRNMI NSSCDQPIGY PIFVSPLTTS YSDSHEQLKD ILGGPISLGN IRNFIVSTWH 1920
RLRKGCGAGC NSGGNIEDSD TGGGTSCTGN NATTANNPHS NVTQGSIGNP GQGSGTGLHP 1980
PVTSYPPTLG TSHSSHSVQS GLVRQSPARA SVASQSSYCY SSRHSSLRMS TTGFVPCRRS 2040
STSQISLRNL PSSIQSRLSM VNQMEPSGQS GLACVQHGLP SSSSSSQSIP ACKHHTLVGF 2100
LATEGGQSSA TDAQPGNTLS PANNSHSRKA EVIYRVQIVD PSQILEGINL SKRKELQWPD 2160
EGIRLKAGRN SWKDWSPQEG MEGHVIHRWV PCSRDPGTRS HIDKAVLLVQ IDDKYVTVIE 2220
TGVLELGAEV 2230 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro. 
Interpro
 IPR007735; Pecanex. 
Pfam
 PF05041; Pecanex_C 
SMART
  
PROSITE
  
PRINTS