UniProt Accession

 XRCC1_MOUSE; Q60596; Q3THC5; Q5U435; Q7TNQ5 

Genbank Protein ID

 U02887; AK168334; BC055900; BC085281 

Genbank Nucleotide ID

 AAA93115.1; BAE40272.1; AAH55900.1; AAH85281.1 

Protein Name

 DNA repair protein XRCC1 

Protein Synonyms/Alias

 X-ray repair cross-complementing protein 1 

Gene Name

 Xrcc1 

Gene Synonyms/Alias

 Xrcc-1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
171	SQKVTVTKLGQFRVK	acetylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. 

Sequence Annotation

 DOMAIN 315 403 BRCT 1.
 DOMAIN 536 627 BRCT 2.
 MOD_RES 142 142 Phosphoserine (By similarity).
 MOD_RES 200 200 Phosphothreonine (By similarity).
 MOD_RES 201 201 Phosphoserine (By similarity).
 MOD_RES 206 206 Phosphoserine (By similarity).
 MOD_RES 213 213 Phosphotyrosine (By similarity).
 MOD_RES 228 228 Phosphoserine (By similarity).
 MOD_RES 261 261 Phosphoserine (By similarity).
 MOD_RES 371 371 Phosphoserine (By similarity).
 MOD_RES 408 408 Phosphoserine (By similarity).
 MOD_RES 409 409 Phosphoserine (By similarity).
 MOD_RES 410 410 Phosphoserine (By similarity).
 MOD_RES 416 416 Phosphoserine (By similarity).
 MOD_RES 418 418 Phosphoserine (By similarity).
 MOD_RES 445 445 Phosphoserine (By similarity).
 MOD_RES 446 446 Phosphoserine.
 MOD_RES 452 452 Phosphothreonine.
 MOD_RES 456 456 Phosphothreonine (By similarity).
 MOD_RES 460 460 Phosphoserine (By similarity).
 MOD_RES 484 484 Phosphoserine.
 MOD_RES 487 487 Phosphothreonine.
 MOD_RES 517 517 Phosphoserine (By similarity).
 MOD_RES 518 518 Phosphothreonine (By similarity).
 MOD_RES 522 522 Phosphothreonine (By similarity).  

Keyword

 3D-structure; Complete proteome; DNA damage; DNA repair; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 631 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003684; F:damaged DNA binding; IEA:InterPro.
 GO:0006281; P:DNA repair; IMP:MGI.
 GO:0021766; P:hippocampus development; IMP:MGI.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0010033; P:response to organic substance; IEA:Compara.
 GO:0000012; P:single strand break repair; IEA:InterPro. 

Interpro

 IPR001357; BRCT_dom.
 IPR008979; Galactose-bd-like.
 IPR002706; Xrcc1_N. 

Pfam

 PF00533; BRCT
 PF01834; XRCC1_N 

SMART

 SM00292; BRCT 

PROSITE

 PS50172; BRCT 

PRINTS