UniProt Accession

 OGFD1_HUMAN; Q8N543; Q9H7U5; Q9H9J9; Q9HA87; Q9HCG0; Q9NVB6 

Genbank Protein ID

 AB046832; AK001688; AK022130; AK022752; AK024314; BC032919 

Genbank Nucleotide ID

 BAB13438.1; BAA91838.1; BAB13967.1; BAB14226.1; BAB14880.1; AAH32919.1 

Protein Name

 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 

Protein Synonyms/Alias

 Termination and polyadenylation 1 homolog 

Gene Name

 OGFOD1 

Gene Synonyms/Alias

 KIAA1612; TPA1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
4	****MNGKRPAEPGP	ubiquitination	[1]
36	AVTEETLKKQVAEAW	ubiquitination	[2]
37	VTEETLKKQVAEAWS	ubiquitination	[1]
91	MNLDFHEKYNDLYKF	ubiquitination	[1]
97	EKYNDLYKFQQSDDL	ubiquitination	[1, 2]
105	FQQSDDLKKRREPHI	ubiquitination	[1, 2]
106	QQSDDLKKRREPHIS	ubiquitination	[1]
117	PHISTLRKILFEDFR	ubiquitination	[1, 3, 4, 5]
194	IDEHFQPKQIVKSLI	ubiquitination	[1]
198	FQPKQIVKSLIPSWN	ubiquitination	[1]
228	SEVLSEEKSRLSISG	ubiquitination	[1, 2]
300	ILLKEFLKPEKFTKV	ubiquitination	[1]
306	LKPEKFTKVCEALEH	ubiquitination	[1]
331	PNKRFYEKAEESKLP	ubiquitination	[1, 2]
336	YEKAEESKLPEILKE	ubiquitination	[1]
379	EEDEMNDKKEAETTD	ubiquitination	[2]
427	EPEENETKKESSVPM	ubiquitination	[2]
428	PEENETKKESSVPMC	ubiquitination	[1]
443	QGELRHWKTGHYTLI	ubiquitination	[1]
511	YRDRETLKFVKHINH	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

 DOMAIN 134 239 Fe2OG dioxygenase.
 METAL 155 155 Iron (By similarity).
 METAL 157 157 Iron (By similarity).
 METAL 218 218 Iron (By similarity).
 BINDING 228 228 2-oxoglutarate (Potential).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Dioxygenase; Iron; Metal-binding; Nucleus; Oxidoreductase; Polymorphism; Reference proteome; Vitamin C. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 542 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
 GO:0016706; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; IEA:InterPro.
 GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW. 

Interpro

 IPR005123; Oxoglu/Fe-dep_dioxygenase.
 IPR019601; Oxoglutarate/Fe-dep_Oase_C.
 IPR006620; Pro_4_hyd_alph. 

Pfam

 PF13640; 2OG-FeII_Oxy_3
 PF10637; Ofd1_CTDD 

SMART

 SM00702; P4Hc 

PROSITE

 PS51471; FE2OG_OXY 

PRINTS