UniProt Accession

 CY250_MOUSE; Q91X77; E9QPJ0; Q6XVG3; Q80X43 

Genbank Protein ID

 AY206873; AC148014; BC011222; BC051050 

Genbank Nucleotide ID

 AAO52736.1; AAH11222.1; AAH51050.1 

Protein Name

 Cytochrome P450 2C50 

Protein Synonyms/Alias

 CYPIIC50 

Gene Name

 Cyp2c50 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
28	RQSSERGKLPPGPTP	ubiquitination	[1]
72	YTLYLGRKPTVVLHG	ubiquitination	[1]
84	LHGYEAVKEALVDHG	ubiquitination	[1]
105	GRLPVFDKATNGMGI	ubiquitination	[1]
116	GMGIIFSKGNVWKNT	ubiquitination	[1]
121	FSKGNVWKNTRRFSL	ubiquitination	[1]
190	FQDRFDYKDRDFLNL	ubiquitination	[1]
200	DFLNLMEKLNEITKI	acetylation	[2]
200	DFLNLMEKLNEITKI	ubiquitination	[1]
235	GSHNKVFKNYACIKN	ubiquitination	[1]
241	FKNYACIKNFLLEKI	ubiquitination	[1]
247	IKNFLLEKIKEHEES	ubiquitination	[1]
249	NFLLEKIKEHEESLD	ubiquitination	[1]
281	ENGNYPLKNRLEHLA	ubiquitination	[1]
322	KYPHVTAKVQEEIEH	ubiquitination	[1]
333	EIEHVIGKHRRPCMQ	ubiquitination	[1]
375	HEVTCDIKFRNYFIP	ubiquitination	[1]
383	FRNYFIPKGTNVITS	ubiquitination	[1]
399	SSVLRDSKEFPNPEK	ubiquitination	[1]
406	KEFPNPEKFDPGHFL	ubiquitination	[1]
418	HFLDENGKFKKSDYF	acetylation	[2]
418	HFLDENGKFKKSDYF	ubiquitination	[1]
420	LDENGKFKKSDYFMP	ubiquitination	[1]
421	DENGKFKKSDYFMPF	ubiquitination	[1]
432	FMPFSTGKRICAGEG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Metabolizes arachidonic acid to several midchain and omega-terminal hydroxyeicosatetraenoic acids (HETE). 

Sequence Annotation

 METAL 435 435 Iron (heme axial ligand) (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 490 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro. 

Interpro

 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 

Pfam

 PF00067; p450 

SMART

  

PROSITE

 PS00086; CYTOCHROME_P450 

PRINTS

 PR00463; EP450I.
 PR00385; P450.