UniProt Accession

 HOME2_RAT; O88801; O88802 

Genbank Protein ID

 AB007689; AB007690 

Genbank Nucleotide ID

 BAA32478.1; BAA32479.1 

Protein Name

 Homer protein homolog 2 

Protein Synonyms/Alias

 Homer-2; Cupidin; VASP/Ena-related gene up-regulated during seizure and LTP 2; Vesl-2 

Gene Name

 Homer2 

Gene Synonyms/Alias

 Vesl2 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
323	KYRQRHLKGELKSFL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. 

Sequence Annotation

 DOMAIN 1 110 WH1.  

Keyword

 Alternative splicing; Cell junction; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Membrane; Postsynaptic cell membrane; Reference proteome; Synapse. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 354 AA 

Protein Sequence

Gene Ontology

 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0030425; C:dendrite; IDA:RGD.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0019904; F:protein domain specific binding; IMP:RGD.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0048148; P:behavioral response to cocaine; IEA:Compara.
 GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Compara.
 GO:0048875; P:chemical homeostasis within a tissue; IEA:Compara.
 GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IEA:Compara. 

Interpro

 IPR000697; EVH1.
 IPR011993; PH_like_dom. 

Pfam

 PF00568; WH1 

SMART

 SM00461; WH1 

PROSITE

 PS50229; WH1 

PRINTS