UniProt Accession

 RNK_HUMAN; Q6P5S7; G3V1Z9; Q502Z2 

Genbank Protein ID

 AC040977; CH471108; AK289930; BC051802; BC062705; BC095436; AM746459 

Genbank Nucleotide ID

 EAW90275.1; BAF82619.1; AAH51802.1; AAH62705.1; AAH95436.1; CAN89245.1 

Protein Name

 Ribonuclease kappa 

Protein Synonyms/Alias

 RNase K; RNase kappa 

Gene Name

 RNASEK 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
132	QVRLNKRKEYMVR**	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Endonuclease; Hydrolase; Membrane; Nuclease; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 137 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004521; F:endoribonuclease activity; IDA:UniProtKB.
 GO:0009303; P:rRNA transcription; IDA:UniProtKB. 

Interpro

 IPR026770; RNase_K. 

Pfam

  

SMART

  

PROSITE

  

PRINTS