CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021862
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 BH3-interacting domain death agonist 
Protein Synonyms/Alias
 p22 BID; BID; BH3-interacting domain death agonist p15; p15 BID; BH3-interacting domain death agonist p13; p13 BID; BH3-interacting domain death agonist p11; p11 BID 
Gene Name
 Bid 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
124GSLSEEDKRNCLAKAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). 
Sequence Annotation
 MOTIF 87 101 BH3 (By similarity).
 MOD_RES 79 79 Phosphoserine (By similarity).  
Keyword
 Apoptosis; Complete proteome; Cytoplasm; Membrane; Mitochondrion; Phosphoprotein; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 196 AA 
Protein Sequence
MDSEVSNGSG LGAEHITNLL VFGFLRNNDR DFHQELEVLG QELPVQVYLE GDREDELQTD 60
GSRASRSFYH GRIEPDSESQ DEVIHNIARH LAQAGDELDH SIQPTLVRQL AAQFMNGSLS 120
EEDKRNCLAK ALDEVKTSFP RDMENDKAML IMTMLLAKKV ASHAPSLLRD VFRTTVNFIN 180
QNLFSYVRDL VRNEMD 196 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0032592; C:integral to mitochondrial membrane; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0007420; P:brain development; IEP:RGD.
 GO:0090150; P:establishment of protein localization to membrane; IEA:Compara.
 GO:0034349; P:glial cell apoptotic process; IEP:RGD.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Compara.
 GO:0032464; P:positive regulation of protein homooligomerization; IEA:Compara.
 GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0006626; P:protein targeting to mitochondrion; IEA:Compara.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IEA:Compara.
 GO:0046902; P:regulation of mitochondrial membrane permeability; IEA:Compara.
 GO:0001836; P:release of cytochrome c from mitochondria; IDA:RGD.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD. 
Interpro
 IPR020728; Bcl2_BH3_motif_CS.
 IPR010479; BID. 
Pfam
 PF06393; BID 
SMART
  
PROSITE
 PS01259; BH3 
PRINTS