UniProt Accession

 VAMP5_HUMAN; O95183; Q9P0T2 

Genbank Protein ID

 AF054825; AF077197; AF151025; BC017891 

Genbank Nucleotide ID

 AAC97473.1; AAD26992.1; AAF36111.1; AAH17891.1 

Protein Name

 Vesicle-associated membrane protein 5 

Protein Synonyms/Alias

 VAMP-5; Myobrevin 

Gene Name

 VAMP5 

Gene Synonyms/Alias

 HSPC191 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
26	IMRNNFGKVLERGVK	acetylation	[1]
26	IMRNNFGKVLERGVK	ubiquitination	[2, 3, 4]
33	KVLERGVKLAELQQR	ubiquitination	[3, 4]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking. 

Sequence Annotation

 DOMAIN 5 65 v-SNARE coiled-coil homology.
 MOD_RES 48 48 Phosphoserine.
 MOD_RES 49 49 Phosphoserine.  

Keyword

 Cell membrane; Coiled coil; Complete proteome; Developmental protein; Differentiation; Golgi apparatus; Membrane; Myogenesis; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 116 AA 

Protein Sequence

Gene Ontology

 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:ProtInc.
 GO:0005802; C:trans-Golgi network; IEA:Compara.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0043001; P:Golgi to plasma membrane protein transport; IEA:Compara.
 GO:0007517; P:muscle organ development; TAS:ProtInc.
 GO:0007519; P:skeletal muscle tissue development; IEA:Compara. 

Interpro

 IPR001388; Synaptobrevin.
 IPR016444; Synaptobrevin_met/fun. 

Pfam

 PF00957; Synaptobrevin 

SMART

  

PROSITE

 PS00417; SYNAPTOBREVIN
 PS50892; V_SNARE 

PRINTS

 PR00219; SYNAPTOBREVN.