UniProt Accession

 ETFA_RAT; P13803; Q5M7W0 

Genbank Protein ID

 M22030; BC088412 

Genbank Nucleotide ID

 AAA41130.1; AAH88412.1 

Protein Name

 Electron transfer flavoprotein subunit alpha, mitochondrial 

Protein Synonyms/Alias

 Alpha-ETF 

Gene Name

 Etfa 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
62	VAGTKCDKVVQDLCK	acetylation	[1]
69	KVVQDLCKVAGVAKV	acetylation	[1]
69	KVVQDLCKVAGVAKV	ubiquitination	[2]
85	VAQHDAYKGLLPEEL	acetylation	[1]
126	LLPRVAAKLNVAPVS	acetylation	[1]
126	LLPRVAAKLNVAPVS	ubiquitination	[2]
139	VSDIIEIKSPDTFVR	acetylation	[1]
139	VSDIIEIKSPDTFVR	ubiquitination	[2]
164	VKCDEKVKVFSVRGT	acetylation	[1]
187	GGSASSEKAPSSSSA	acetylation	[1]
203	ISEWLDQKLTKSDRP	acetylation	[1]
226	VSGGRGLKSGENFKL	acetylation	[1]
226	VSGGRGLKSGENFKL	ubiquitination	[2]
294	LAGMKDSKTIVAINK	ubiquitination	[2]
301	KTIVAINKDPEAPIF	acetylation	[1]
331	PEMTEILKKK*****	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). 

Sequence Annotation

 NP_BIND 274 302 FAD (Potential).  

Keyword

 Complete proteome; Direct protein sequencing; Electron transport; FAD; Flavoprotein; Mitochondrion; Reference proteome; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 333 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0009055; F:electron carrier activity; NAS:RGD.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:Compara.
 GO:0016491; F:oxidoreductase activity; IEA:Compara.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. 

Interpro

 IPR001308; ETF_a.
 IPR014730; ETF_a/b_N.
 IPR014731; ETF_asu_C.
 IPR018206; ETF_asu_C_CS.
 IPR014729; Rossmann-like_a/b/a_fold. 

Pfam

 PF01012; ETF
 PF00766; ETF_alpha 

SMART

 SM00893; ETF 

PROSITE

 PS00696; ETF_ALPHA 

PRINTS