UniProt Accession

 B7ZC50_MOUSE; B7ZC50 

Genbank Protein ID

 AC152827; AL596265 

Genbank Nucleotide ID

  

Protein Name

 Heat shock protein HSP 90-alpha 

Protein Synonyms/Alias

  

Gene Name

 Hsp90aa1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
112	NNLGTIAKSGTKAFM	acetylation	[1, 2]
112	NNLGTIAKSGTKAFM	succinylation	[2]
112	NNLGTIAKSGTKAFM	ubiquitination	[3]
185	EPMGRGTKVILHLKE	ubiquitination	[3]
191	TKVILHLKEDQTEYL	acetylation	[1]
191	TKVILHLKEDQTEYL	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0031526; C:brush border membrane; IEA:Compara.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0031012; C:extracellular matrix; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0016887; F:ATPase activity; IEA:Compara.
 GO:0002135; F:CTP binding; IEA:Compara.
 GO:0032564; F:dATP binding; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:Compara.
 GO:0003729; F:mRNA binding; IEA:Compara.
 GO:0030235; F:nitric-oxide synthase regulator activity; IEA:Compara.
 GO:0042803; F:protein homodimerization activity; IDA:MGI.
 GO:0002134; F:UTP binding; IEA:Compara.
 GO:0010659; P:cardiac muscle cell apoptotic process; IEA:Compara.
 GO:0051131; P:chaperone-mediated protein complex assembly; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0060452; P:positive regulation of cardiac muscle contraction; IEA:Compara.
 GO:0045793; P:positive regulation of cell size; IEA:Compara.
 GO:0010592; P:positive regulation of lamellipodium assembly; IEA:Compara.
 GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Compara.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0045040; P:protein import into mitochondrial outer membrane; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0009408; P:response to heat; IEA:Compara.
 GO:0009651; P:response to salt stress; IEA:Compara.
 GO:0003009; P:skeletal muscle contraction; IEA:Compara. 

Interpro

 IPR003594; HATPase_ATP-bd.
 IPR019805; Heat_shock_protein_90_CS.
 IPR001404; Hsp90.
 IPR020575; Hsp90_N. 

Pfam

 PF02518; HATPase_c 

SMART

 SM00387; HATPase_c 

PROSITE

 PS00298; HSP90 

PRINTS

 PR00775; HEATSHOCK90.