| Tag | Content |
|---|
| CPLM ID | CPLM-024260 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase |
Protein Synonyms/Alias | Tetrahydrodipicolinate N-succinyltransferase; THDP succinyltransferase; THP succinyltransferase; Tetrahydropicolinate succinylase |
Gene Name | dapD |
Gene Synonyms/Alias | MSMEG_5104; MSMEI_4976 |
Created Date | July 27, 2013 |
Organism | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) |
NCBI Taxa ID | 246196 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 299 | SGAVEVVKRDGTGIT | pupylation | [1] |
|
Reference | [1] Proteome-wide identification of mycobacterial pupylation targets. Poulsen C, Akhter Y, Jeon AH, Schmitt-Ulms G, Meyer HE, Stefanski A, Stühler K, Wilmanns M, Song YH. Mol Syst Biol. 2010 Jul 13;6:386. [ PMID: 20631680] |
Functional Description | Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity). |
Sequence Annotation | REGION 254 255 Succinyl-CoA binding (By similarity).
REGION 287 290 Succinyl-CoA binding (By similarity).
ACT_SITE 196 196 Acyl-anhydride intermediate (By
METAL 163 163 Magnesium 1; shared with trimeric
METAL 180 180 Magnesium 2; shared with trimeric
BINDING 198 198 Succinyl-CoA (By similarity).
BINDING 213 213 Succinyl-CoA; via amide nitrogen (By
BINDING 216 216 Succinyl-CoA (By similarity).
BINDING 239 239 Succinyl-CoA; via amide nitrogen (By
BINDING 262 262 Succinyl-CoA; via carbonyl oxygen (By
BINDING 274 274 Succinyl-CoA (By similarity). |
Keyword | Acyltransferase; Amino-acid biosynthesis; Complete proteome; Cytoplasm; Diaminopimelate biosynthesis; Lysine biosynthesis; Magnesium; Metal-binding; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 314 AA |
Protein Sequence | MTAASGIGLA TITADGTVLD TWFPAPELSA SGPAGTARLT GDDVPADLAA LTGKDEDRDV 60
EVVAVRTTIA DLNDKPADTH DVWLRLHLLS HRLTKPHEAN LDGIFGLLSN VVWTNFGPCA 120
VEGFETTRAR LRKRGAVAVY GIDKFPRMVD YVTPSGVRIA DADRVRLGAH LASGTTVMHE 180
GFVNFNAGTL GTSMVEGRIS AGVVVDDGSD IGGGASIMGT LSGGGKEVIK VGKRCLLGAN 240
SGLGISLGDD CVVEAGLYVT GGTKVTTADG QVTKAIELSG ASNLLFRRNS LSGAVEVVKR 300
DGTGITLNEA LHAN 314 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0008666; F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity; IEA:HAMAP. GO:0000287; F:magnesium ion binding; IEA:HAMAP. GO:0019877; P:diaminopimelate biosynthetic process; IEA:HAMAP. GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:HAMAP. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |