| Tag | Content |
|---|
| CPLM ID | CPLM-015108 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ankyrin repeat domain-containing protein 54 |
Protein Synonyms/Alias | Lyn-interacting ankyrin repeat protein |
Gene Name | ANKRD54 |
Gene Synonyms/Alias | LIAR |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 85 | PRDELRCKIPAGRLR | ubiquitination | [1] | | 106 | RRLGPTGKEVHALKR | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation (By similarity). |
Sequence Annotation | REPEAT 109 138 ANK 1.
REPEAT 142 171 ANK 2.
REPEAT 175 204 ANK 3.
REPEAT 208 244 ANK 4.
REGION 99 117 Nuclear localization signal (NLS) (By
REGION 141 241 LYN-binding (By similarity).
REGION 283 293 Nuclear export signal (NES) (By
MOD_RES 2 2 N-acetylalanine.
MOD_RES 58 58 Phosphoserine.
MOD_RES 63 63 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; ANK repeat; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 300 AA |
Protein Sequence | MAAAAGDADD EPRSGHSSSE GECAVAPEPL TDAEGLFSFA DFGSALGGGG AGLSGRASGG 60
AQSPLRYLHV LWQQDAEPRD ELRCKIPAGR LRRAARPHRR LGPTGKEVHA LKRLRDSANA 120
NDVETVQQLL EDGADPCAAD DKGRTALHFA SCNGNDQIVQ LLLDHGADPN QRDGLGNTPL 180
HLAACTNHVP VITTLLRGGA RVDALDRAGR TPLHLAKSKL NILQEGHAQC LEAVRLEVKQ 240
IIHMLREYLE RLGQHEQRER LDDLCTRLQM TSTKEQVDEV TDLLASFTSL SLQMQSMEKR 300 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0030496; C:midbody; ISS:UniProtKB. GO:0005634; C:nucleus; ISS:UniProtKB. GO:0019887; F:protein kinase regulator activity; IEA:Compara. GO:0007049; P:cell cycle; IEA:Compara. GO:0006913; P:nucleocytoplasmic transport; IEA:Compara. GO:0045648; P:positive regulation of erythrocyte differentiation; ISS:UniProtKB. GO:0010627; P:regulation of intracellular protein kinase cascade; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |