Tag | Content |
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CPLM ID | CPLM-015872 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CUGBP Elav-like family member 4 |
Protein Synonyms/Alias | CELF-4; Bruno-like protein 4; CUG-BP- and ETR-3-like factor 4; RNA-binding protein BRUNOL-4 |
Gene Name | Celf4 |
Gene Synonyms/Alias | Brul4; Brunol4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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68 | IPRNLDEKDLKPLFE | ubiquitination | [1] | 71 | NLDEKDLKPLFEEFG | ubiquitination | [1] | 87 | IYELTVLKDRFTGMH | ubiquitination | [1] | 153 | QPPSQDRKLFVGMLN | ubiquitination | [1] | 161 | LFVGMLNKQQSEDDV | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity). |
Sequence Annotation | DOMAIN 54 135 RRM 1. DOMAIN 152 232 RRM 2. DOMAIN 406 479 RRM 3. REGION 1 298 Sufficient for RNA-binding and MSE- REGION 239 258 Necessary for TNNT2 exon 5 inclusion (By |
Keyword | Activator; Alternative splicing; Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 486 AA |
Protein Sequence | MYIKMATLAN GQADNASLST NGLGSSPGSA GHMNGLSHSP GNPSTIPMKD HDAIKLFIGQ 60 IPRNLDEKDL KPLFEEFGKI YELTVLKDRF TGMHKGCAFL TYCERESALK AQSALHEQKT 120 LPGMNRPIQV KPADSESRGG SSCLRQPPSQ DRKLFVGMLN KQQSEDDVRR LFEAFGNIEE 180 CTILRGPDGN SKGCAFVKYS SHAEAQAAIN ALHGSQTMPG ASSSLVVKFA DTDKERTMRR 240 MQQMAGQMGM FNPMAIPFGA YGAYAQALMQ QQAALMASVA QGGYLNPMAA FAAAQMQQMA 300 ALNMNGLAAA PMTPTSGGST PPGITAPAVP SIPSPIGVNG FTGLPPQANG QPAAEAVFAN 360 GIHPYPAQSP TAADPLQQAY AGVQQYAGPA AYPAAYGQIS QAFPQPPPMI PQQQREGPEG 420 CNLLIYHLPQ EFGDAELMQM FLPFGFVSFD NPASAQTAIQ AMNGFQIGMK RLKVQLKRPK 480 DANRPY 486 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; ISS:MGI. GO:0042835; F:BRE binding; ISS:UniProtKB. GO:0003729; F:mRNA binding; IDA:MGI. GO:0000166; F:nucleotide binding; IEA:InterPro. GO:0000380; P:alternative mRNA splicing, via spliceosome; IEA:Compara. GO:0006376; P:mRNA splice site selection; IDA:MGI. GO:0090394; P:negative regulation of excitatory postsynaptic membrane potential; IMP:MGI. GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; ISS:UniProtKB. GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:Compara. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |