CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038430
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tropomyosin alpha-1 chain 
Protein Synonyms/Alias
  
Gene Name
 Tpm1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
37KAAEDRSKQLEDELVubiquitination[1]
48DELVSLQKKLKGTEDacetylation[2, 3]
48DELVSLQKKLKGTEDubiquitination[1]
49ELVSLQKKLKGTEDEubiquitination[1]
51VSLQKKLKGTEDELDubiquitination[1]
59GTEDELDKYSEALKDacetylation[2]
59GTEDELDKYSEALKDubiquitination[1]
65DKYSEALKDAQEKLEubiquitination[1]
70ALKDAQEKLELAEKKubiquitination[1]
76EKLELAEKKATDAEAubiquitination[1]
77KLELAEKKATDAEADubiquitination[4]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] A proteomics approach to identify the ubiquitinated proteins in mouse heart.
 Jeon HB, Choi ES, Yoon JH, Hwang JH, Chang JW, Lee EK, Choi HW, Park ZY, Yoo YJ.
 Biochem Biophys Res Commun. 2007 Jun 8;357(3):731-6. [PMID: 17451654] 
Functional Description
  
Sequence Annotation
  
Keyword
 Coiled coil; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 284 AA 
Protein Sequence
MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY 60
SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA 120
DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE 180
ERAELSEGQV RQLEEQLRIM DQTLKALMAA EDKYSQKEDK YEEEIKVLSD KLKEAETRAE 240
FAERSVTKLE KSIDDLEEKV AHAKEENLSM HQMLDQTLLE LNNM 284 
Gene Ontology
 GO:0005862; C:muscle thin filament tropomyosin; TAS:MGI.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI. 
Interpro
 IPR000533; Tropomyosin. 
Pfam
 PF00261; Tropomyosin 
SMART
  
PROSITE
 PS00326; TROPOMYOSIN 
PRINTS
 PR00194; TROPOMYOSIN.