CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039992
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 TATA box-binding protein-associated factor RNA polymerase I subunit C 
Protein Synonyms/Alias
  
Gene Name
 TAF1C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
57VAFAPLGKLMLENFKubiquitination[1]
64KLMLENFKLEGAGSRubiquitination[1, 2, 3]
191DNPQFLGKPGRIQLQubiquitination[1, 2, 3, 4]
230CAVWKFGKQWQPTLLubiquitination[1, 2]
316VGDRTGVKMLDTQGPubiquitination[1, 3, 5]
341GAEASCQKGERVLLTubiquitination[1, 2, 3]
386LPLVPMLKWNHGLPSubiquitination[1, 5]
459AFPLLEPKIQWRLQEubiquitination[1, 2, 4]
548AGCSQWLKALLKVPLubiquitination[1]
552QWLKALLKVPLAPPVubiquitination[1, 3, 5]
623PESGLEDKLSERLGEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 776 AA 
Protein Sequence
MLPPLIDPWD PGLTARDLLF RGGCRYRKRP RVVLDVTEQI SRFLLDHGDV AFAPLGKLML 60
ENFKLEGAGS RTKKKTVVSV KKLLQDLGGH QPWGCPWAYL SNRQRRFSIL GGPILGTSVA 120
SHLAELLHEE LVLRWEQLLL DEACTGGALA WVPGRTPQFG QLVYPAGGAQ DRLHFQEVVL 180
TPGDNPQFLG KPGRIQLQGP VRQVVTCTVQ GETLLAVRSD YHCAVWKFGK QWQPTLLQAM 240
QVEKGATGIS LSPHLPGELA ICSRSGAVCL WSPEDGLRQI YRDPETLVFR DSSSWRWADF 300
TAHPRVLTVG DRTGVKMLDT QGPPGCGLLL FRLGAEASCQ KGERVLLTQY LGHSSPKCLP 360
PTLHLVCTQF SLYLVDERLP LVPMLKWNHG LPSPLLLARL LPPPRPSCVQ PLLLGGQGGQ 420
LQLLHLAGEG ASVPRLAGPP QSLPSRIDSL PAFPLLEPKI QWRLQERLKA PTIGLAAVVP 480
PLPSAPTPGL VLFQLSAAGD VFYQQLRPQV DSSLRRDAGP PGDTQPDCHA PTASWTSQDT 540
AGCSQWLKAL LKVPLAPPVW TAPTFTHRQM LGSTELRREE EEGQRLGVLR KAMARGQLLL 600
QRDLGSLPAA EPPPAPESGL EDKLSERLGE AWAGRGAAWW ERQQGRTSEP GRQTRRPKRR 660
TQLSSSFSLS GHVDPSEDTS SPHSPEWPPA DALPLPPTTP PSQELTPDAC AQGVPSEQRQ 720
MLRDYMAKLP PQRDTPGCAT TPPHSQASSV RATRSQQHTP VLSSSQPLRK KPRMGF 776 
Gene Ontology
  
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
  
SMART
  
PROSITE
  
PRINTS