CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031494
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Schlafen family member 5 
Protein Synonyms/Alias
 cDNA FLJ52101 
Gene Name
 SLFN5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
38MDPRLREKQNEIILRubiquitination[1]
65IKAEIENKGYNYERHubiquitination[1, 2, 3, 4]
138QEALAFLKCRTQTPTubiquitination[1, 5]
245VIGCEKEKIDLTSLRubiquitination[1]
260ASIDGCIKKLPVHHFubiquitination[1]
286NFLEVHDKGALRGYVubiquitination[1]
316VPSSWQVKDNRVRQLubiquitination[1, 5]
365SKPVCIHKNSECLKEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 389 AA 
Protein Sequence
MSLRIDVDTN FPECVVDAGK VTLGTQQRQE MDPRLREKQN EIILRAVCAL LNSGGGIIKA 60
EIENKGYNYE RHGVGLDVPP IFRSHLDKMQ KENHFLIFVK SWNTEAGVPL ATLCSNLYHR 120
ERTSTDVMDS QEALAFLKCR TQTPTNINVS NSLGPQAAQG SVQYEGNINV SAAALFDRKR 180
LQYLEKLNLP ESTHVEFVMF STDVSHCVKD RLPKCVSAFA NTEGGYVFFG VHDETCQVIG 240
CEKEKIDLTS LRASIDGCIK KLPVHHFCTQ RPEIKYVLNF LEVHDKGALR GYVCAIKVEK 300
FCCAVFAKVP SSWQVKDNRV RQLPTREWTA WMMEADPDLS RCPEMVLQLS LSSATPRSKP 360
VCIHKNSECL KEQQKRYFPV SARKTSASQ 389 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro. 
Interpro
 IPR007421; ATPase_AAA-4. 
Pfam
 PF04326; AAA_4 
SMART
  
PROSITE
  
PRINTS