CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010732
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable phospholipid-transporting ATPase ID 
Protein Synonyms/Alias
 ATPase class I type 8B member 2 
Gene Name
 ATP8B2 
Gene Synonyms/Alias
 ATPID; KIAA1137 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
243PPNNKLDKFSGTLYWubiquitination[1]
593GKIRLYCKGADTILLubiquitination[2]
769NGFTYQDKLSSSKLTubiquitination[2]
1125RFLRLNLKPDLSDTVubiquitination[2]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 ACT_SITE 411 411 4-aspartylphosphate intermediate (By
 METAL 833 833 Magnesium (By similarity).
 METAL 837 837 Magnesium (By similarity).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Hydrolase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1209 AA 
Protein Sequence
MDTLRAVPLF SISGLFSFPY RVSHGIAGIL LGEMAVCAKK RPPEEERRAR ANDREYNEKF 60
QYASNCIKTS KYNILTFLPV NLFEQFQEVA NTYFLFLLIL QLIPQISSLS WFTTIVPLVL 120
VLTITAVKDA TDDYFRHKSD NQVNNRQSQV LINGILQQEQ WMNVCVGDII KLENNQFVAA 180
DLLLLSSSEP HGLCYIETAE LDGETNMKVR QAIPVTSELG DISKLAKFDG EVICEPPNNK 240
LDKFSGTLYW KENKFPLSNQ NMLLRGCVLR NTEWCFGLVI FAGPDTKLMQ NSGRTKFKRT 300
SIDRLMNTLV LWIFGFLVCM GVILAIGNAI WEHEVGMRFQ VYLPWDEAVD SAFFSGFLSF 360
WSYIIILNTV VPISLYVSVE VIRLGHSYFI NWDKKMFCMK KRTPAEARTT TLNEELGQVE 420
YIFSDKTGTL TQNIMVFNKC SINGHSYGDV FDVLGHKAEL GERPEPVDFS FNPLADKKFL 480
FWDPSLLEAV KIGDPHTHEF FRLLSLCHTV MSEEKNEGEL YYKAQSPDEG ALVTAARNFG 540
FVFRSRTPKT ITVHEMGTAI TYQLLAILDF NNIRKRMSVI VRNPEGKIRL YCKGADTILL 600
DRLHHSTQEL LNTTMDHLNE YAGEGLRTLV LAYKDLDEEY YEEWAERRLQ ASLAQDSRED 660
RLASIYEEVE NNMMLLGATA IEDKLQQGVP ETIALLTLAN IKIWVLTGDK QETAVNIGYS 720
CKMLTDDMTE VFIVTGHTVL EVREELRKAR EKMMDSSRSV GNGFTYQDKL SSSKLTSVLE 780
AVAGEYALVI NGHSLAHALE ADMELEFLET ACACKAVICC RVTPLQKAQV VELVKKYKKA 840
VTLAIGDGAN DVSMIKTAHI GVGISGQEGI QAVLASDYSF SQFKFLQRLL LVHGRWSYLR 900
MCKFLCYFFY KNFAFTMVHF WFGFFCGFSA QTVYDQYFIT LYNIVYTSLP VLAMGVFDQD 960
VPEQRSMEYP KLYEPGQLNL LFNKREFFIC IAQGIYTSVL MFFIPYGVFA DATRDDGTQL 1020
ADYQSFAVTV ATSLVIVVSV QIGLDTGYWT AINHFFIWGS LAVYFAILFA MHSNGLFDMF 1080
PNQFRFVGNA QNTLAQPTVW LTIVLTTVVC IMPVVAFRFL RLNLKPDLSD TVRYTQLVRK 1140
KQKAQHRCMR RVGRTGSRRS GYAFSHQEGF GELIMSGKNM RLSSLALSSF TTRSSSSWIE 1200
SLRRKKSDSA SSPSGGADKP LKG 1223 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0019829; F:cation-transporting ATPase activity; IEA:InterPro.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0004012; F:phospholipid-translocating ATPase activity; IEA:EC.
 GO:0034220; P:ion transmembrane transport; TAS:Reactome. 
Interpro
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR018303; ATPase_P-typ_P_site.
 IPR006539; ATPase_P-typ_Plipid-transp.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom. 
Pfam
 PF00122; E1-E2_ATPase 
SMART
  
PROSITE
 PS00154; ATPASE_E1_E2 
PRINTS
 PR00119; CATATPASE.