CPLM-000320

Genbank Nucleotide ID

PDZ domain-containing protein GIPC1

Protein Synonyms/Alias

GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; RGS19-interacting protein 1; Tax interaction protein 2; TIP-2

C19orf3; GIPC; RGS19IP1

Homo sapiens (Human)

Position	Peptide	Type	References
10	LGLGRRKKAPPLVEN	ubiquitination	[1, 2]
80	IEGFTNVKELYGKIA	ubiquitination	[1, 2, 3, 4, 5, 6, 7]
128	DFIFAHVKGQRKEVE	ubiquitination	[1, 5]
199	YEVARLLKELPRGRT	ubiquitination	[5]
210	RGRTFTLKLTEPRKA	ubiquitination	[1, 5]
216	LKLTEPRKAFDMISQ	ubiquitination	[4, 5]
263	LPSAFEEKAIEKVDD	ubiquitination	[1]

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
[3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
[5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
[7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]

Functional Description

May be involved in G protein-linked signaling.

DOMAIN 133 213 PDZ.
MOD_RES 225 225 Phosphoserine.
MOD_RES 232 232 Phosphoserine.

Alternative splicing; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005903; C:brush border; IEA:Compara.
GO:0005938; C:cell cortex; IDA:UniProtKB.
GO:0005829; C:cytosol; ISS:UniProtKB.
GO:0043198; C:dendritic shaft; ISS:BHF-UCL.
GO:0043197; C:dendritic spine; ISS:BHF-UCL.
GO:0030139; C:endocytic vesicle; IEA:Compara.
GO:0008021; C:synaptic vesicle; ISS:BHF-UCL.
GO:0012506; C:vesicle membrane; ISS:BHF-UCL.
GO:0003779; F:actin binding; ISS:BHF-UCL.
GO:0017022; F:myosin binding; ISS:BHF-UCL.
GO:0042803; F:protein homodimerization activity; ISS:BHF-UCL.
GO:0043542; P:endothelial cell migration; ISS:BHF-UCL.
GO:0007186; P:G-protein coupled receptor signaling pathway; NAS:UniProtKB.
GO:0014047; P:glutamate secretion; ISS:BHF-UCL.
GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:BHF-UCL.
GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; ISS:BHF-UCL.
GO:0006605; P:protein targeting; ISS:BHF-UCL.
GO:0031647; P:regulation of protein stability; ISS:BHF-UCL.
GO:0048167; P:regulation of synaptic plasticity; ISS:BHF-UCL.
GO:0007268; P:synaptic transmission; ISS:BHF-UCL.

IPR001478; PDZ.
IPR017379; UCP038083_PDZ.