UniProt Accession

 PSMD6_HUMAN; Q15008; A8K2E0 

Genbank Protein ID

 AF215935; AF530062; AY568086; D14663; AK290205; CH471055; BC000630; BC000904; BC012369 

Genbank Nucleotide ID

 AAF65540.1; AAQ09946.1; AAS68366.1; BAA03497.1; BAF82894.1; EAW65424.1; AAH00630.1; AAH00904.1; AAH12369.1 

Protein Name

 26S proteasome non-ATPase regulatory subunit 6 

Protein Synonyms/Alias

 26S proteasome regulatory subunit RPN7; 26S proteasome regulatory subunit S10; Breast cancer-associated protein SGA-113M; Phosphonoformate immuno-associated protein 4; Proteasome regulatory particle subunit p44S10; p42A 

Gene Name

 PSMD6 

Gene Synonyms/Alias

 KIAA0107; PFAAP4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
93	EELEDAEKNLGESEI	ubiquitination	[1]
107	IRDAMMAKAEYLCRI	ubiquitination	[1, 2]
130	AFRKTYDKTVALGHR	ubiquitination	[1]
242	DLREKVIKGAEILEV	ubiquitination	[1, 3]
349	RLHCKIDKVNEIVET	ubiquitination	[1]
362	ETNRPDSKNWQYQET	ubiquitination	[1, 3, 4]
371	WQYQETIKKGDLLLN	ubiquitination	[1, 3]
372	QYQETIKKGDLLLNR	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. 

Sequence Annotation

 DOMAIN 191 358 PCI.  

Keyword

 Complete proteome; Proteasome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 389 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
 GO:0016887; F:ATPase activity; NAS:UniProtKB.
 GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.
 GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.
 GO:0006915; P:apoptotic process; TAS:Reactome.
 GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome.
 GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome.
 GO:0010467; P:gene expression; TAS:Reactome.
 GO:0016071; P:mRNA metabolic process; TAS:Reactome.
 GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
 GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
 GO:0000209; P:protein polyubiquitination; TAS:Reactome.
 GO:0042981; P:regulation of apoptotic process; TAS:Reactome.
 GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome.
 GO:0016032; P:viral reproduction; TAS:Reactome. 

Interpro

 IPR019585; 26S_proteasome_reg_su-Rpn7.
 IPR000717; PCI_dom.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF01399; PCI
 PF10602; RPN7 

SMART

 SM00088; PINT 

PROSITE

  

PRINTS