Tag | Content |
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CPLM ID | CPLM-010881 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | General transcription factor IIF subunit 2 |
Protein Synonyms/Alias | ATP-dependent helicase GTF2F2; Transcription initiation factor IIF subunit beta; TFIIF-beta; Transcription initiation factor RAP30 |
Gene Name | Gtf2f2 |
Gene Synonyms/Alias | Rap30 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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42 | PGRGEVGKLRIAKNQ | acetylation | [1] | 71 | NIHDIGGKPASVSAP | acetylation | [1] | 137 | LQIEESSKPVRLSQQ | acetylation | [1] | 154 | KVVTTNYKPVANHQY | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA- helicase activity (By similarity). |
Sequence Annotation | NP_BIND 36 43 ATP (By similarity). MOD_RES 2 2 N-acetylalanine (By similarity). MOD_RES 22 22 N6-acetyllysine (By similarity). MOD_RES 33 33 N6-acetyllysine (By similarity). MOD_RES 137 137 N6-acetyllysine (By similarity). MOD_RES 142 142 Phosphoserine (By similarity). MOD_RES 248 248 Phosphoserine (By similarity). |
Keyword | Acetylation; ATP-binding; Complete proteome; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 249 AA |
Protein Sequence | MAERGELDLT GAKQNTGVWL VKVPKYLSQQ WAKAPGRGEV GKLRIAKNQG RTEVSFTLNE 60 DLANIHDIGG KPASVSAPRE HPFVLQSVGG QTLTVFTESS SDKLSLEGIV VQRAECRPAA 120 SENYMKLKRL QIEESSKPVR LSQQADKVVT TNYKPVANHQ YNIEYERKKK EDGKRARADK 180 QHVLDMLFSA FEKHQYYNLK DLVDITKQPV GYLKEILKEI GIQNVKGIHK NTWELKPEYR 240 HYQTEEKSD 249 |
Gene Ontology | GO:0005674; C:transcription factor TFIIF complex; IEA:InterPro. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:RGD. GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:InterPro. |
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