| Tag | Content |
|---|
| CPLM ID | CPLM-023398 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Alanine--tRNA ligase, cytoplasmic |
Protein Synonyms/Alias | Alanyl-tRNA synthetase; AlaRS |
Gene Name | Aats-ala |
Gene Synonyms/Alias | alaS; CG13391 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 7 | *MKLLTAKEVRNAYL | acetylation | [1] | | 487 | TNDTFKYKYEAVSDE | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity). |
Sequence Annotation | METAL 604 604 Zinc (Potential).
METAL 608 608 Zinc (Potential).
METAL 723 723 Zinc (Potential).
METAL 727 727 Zinc (Potential). |
Keyword | Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Ligase; Metal-binding; Nucleotide-binding; Protein biosynthesis; Reference proteome; RNA-binding; tRNA-binding; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 966 AA |
Protein Sequence | MKLLTAKEVR NAYLDFFKEQ KHIYVHSSST IPLDDPTLLF ANAGMNQFKP IFLGTADPNS 60
EMSKWVRVAN TQKCIRAGGK HNDLDDVGKD VYHHTFFEML GNWSFGDYFK KEICSWAWEF 120
LTQRLALPKD RLYVTYFGGD AASGLEPDLE CKQMWLDLGL KPEHILPGSM KDNFWEMGET 180
GPCGPCSELH FDRIGGRSVP ELVNMDDPDV LEIWNLVFIQ YNRESDGSLK QLPKKHIDCG 240
MGFERLVSVI QNKRSNYDTD LFVPLFDAIQ AGTGAPPYQG RVGADDVDGI DMAYRVLADH 300
ARTITIALAD GGTPDNTGRG YVLRRILRRA VRYATEKLNA KPGFFATLVN TVVDLLGDAF 360
PEVKKDPQHI IDIINEEELQ FLKTLTRGRN LLNRTIEKLG NQTTIPGDVA WRLYDTYGFP 420
VDLTQLMAEE KSLKIDMDGY EAAKHNSYVL SQGKGASKIE EINLDVHAIS QLQEQGVPPT 480
NDTFKYKYEA VSDERDSAYN YGVCNSKIVA LRFENQFVNE ITSGQKAGIV LDKTNFYAES 540
GGQIYDQGAL VKVNDEANEF LVDRVYNRGG YILHIGVVEG TLKVGDELEL HIDVERRWLT 600
MKNHSATHAL NHCLLQVLGK DTEQKGSLVV PEKLRFDFNS KAAMTIEQVS KTEQLTKEMV 660
YKNVPIYAKE SKLALAKKIR GLRSVFDEVY PDPVRVISFG VPVDELEQNP DSEAGEQTSV 720
EFCGGTHLRR SGHIMDFVIS SEEAIAKGIR RIVALTGPEA LKALKKSEAF EQEIVRLKAT 780
IDNDKSGKDS KSHVKEIVEL TEQISHATIP YVKKDEMRNL LKGLKKTLDD KERALRAAVS 840
VTVVERAKTL CEANPNATVL VEQLEAFNNT KALDAALKQV RSQLPDAAAM FLSVDADSKK 900
IFCLSSVPKS AVEKGLKANE WVQHVSATLG GKGGGKPESA QASGTNYEKV DEIVQLASKF 960
AQSKLS 966 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |