CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004557
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Integrin alpha-2 
Protein Synonyms/Alias
 CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD49b 
Gene Name
 ITGA2 
Gene Synonyms/Alias
 CD49B 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
603IRTKYSQKILGSDGAubiquitination[1]
779EAYSETAKVFSIPFHubiquitination[1]
821FIVSNQNKRLTFSVTubiquitination[2]
830LTFSVTLKNKRESAYubiquitination[2]
1038TSSSVSFKSENFRHTubiquitination[1]
1168RKYEKMTKNPDEIDEubiquitination[1, 2, 3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. 
Sequence Annotation
 REPEAT 34 92 FG-GAP 1.
 REPEAT 101 161 FG-GAP 2.
 DOMAIN 188 365 VWFA.
 REPEAT 366 420 FG-GAP 3.
 REPEAT 423 477 FG-GAP 4.
 REPEAT 478 539 FG-GAP 5.
 REPEAT 540 598 FG-GAP 6.
 REPEAT 602 664 FG-GAP 7.
 REGION 1155 1161 Interaction with HPS5.
 MOTIF 1157 1161 GFFKR motif.
 CARBOHYD 105 105 N-linked (GlcNAc...) (Potential).
 CARBOHYD 112 112 N-linked (GlcNAc...) (Potential).
 CARBOHYD 343 343 N-linked (GlcNAc...).
 CARBOHYD 432 432 N-linked (GlcNAc...) (Potential).
 CARBOHYD 460 460 N-linked (GlcNAc...) (Potential).
 CARBOHYD 475 475 N-linked (GlcNAc...) (Potential).
 CARBOHYD 699 699 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1057 1057 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1074 1074 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1081 1081 N-linked (GlcNAc...) (Potential).
 DISULFID 83 92 By similarity.
 DISULFID 680 737 By similarity.
 DISULFID 789 795 By similarity.
 DISULFID 865 876 By similarity.
 DISULFID 1019 1050 By similarity.
 DISULFID 1055 1060 By similarity.  
Keyword
 3D-structure; Calcium; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Host cell receptor for virus entry; Host-virus interaction; Integrin; Magnesium; Membrane; Metal-binding; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1181 AA 
Protein Sequence
MGPERTGAAP LPLLLVLALS QGILNCCLAY NVGLPEAKIF SGPSSEQFGY AVQQFINPKG 60
NWLLVGSPWS GFPENRMGDV YKCPVDLSTA TCEKLNLQTS TSIPNVTEMK TNMSLGLILT 120
RNMGTGGFLT CGPLWAQQCG NQYYTTGVCS DISPDFQLSA SFSPATQPCP SLIDVVVVCD 180
ESNSIYPWDA VKNFLEKFVQ GLDIGPTKTQ VGLIQYANNP RVVFNLNTYK TKEEMIVATS 240
QTSQYGGDLT NTFGAIQYAR KYAYSAASGG RRSATKVMVV VTDGESHDGS MLKAVIDQCN 300
HDNILRFGIA VLGYLNRNAL DTKNLIKEIK AIASIPTERY FFNVSDEAAL LEKAGTLGEQ 360
IFSIEGTVQG GDNFQMEMSQ VGFSADYSSQ NDILMLGAVG AFGWSGTIVQ KTSHGHLIFP 420
KQAFDQILQD RNHSSYLGYS VAAISTGEST HFVAGAPRAN YTGQIVLYSV NENGNITVIQ 480
AHRGDQIGSY FGSVLCSVDV DKDTITDVLL VGAPMYMSDL KKEEGRVYLF TIKKGILGQH 540
QFLEGPEGIE NTRFGSAIAA LSDINMDGFN DVIVGSPLEN QNSGAVYIYN GHQGTIRTKY 600
SQKILGSDGA FRSHLQYFGR SLDGYGDLNG DSITDVSIGA FGQVVQLWSQ SIADVAIEAS 660
FTPEKITLVN KNAQIILKLC FSAKFRPTKQ NNQVAIVYNI TLDADGFSSR VTSRGLFKEN 720
NERCLQKNMV VNQAQSCPEH IIYIQEPSDV VNSLDLRVDI SLENPGTSPA LEAYSETAKV 780
FSIPFHKDCG EDGLCISDLV LDVRQIPAAQ EQPFIVSNQN KRLTFSVTLK NKRESAYNTG 840
IVVDFSENLF FASFSLPVDG TEVTCQVAAS QKSVACDVGY PALKREQQVT FTINFDFNLQ 900
NLQNQASLSF QALSESQEEN KADNLVNLKI PLLYDAEIHL TRSTNINFYE ISSDGNVPSI 960
VHSFEDVGPK FIFSLKVTTG SVPVSMATVI IHIPQYTKEK NPLMYLTGVQ TDKAGDISCN 1020
ADINPLKIGQ TSSSVSFKSE NFRHTKELNC RTASCSNVTC WLKDVHMKGE YFVNVTTRIW 1080
NGTFASSTFQ TVQLTAAAEI NTYNPEIYVI EDNTVTIPLM IMKPDEKAEV PTGVIIGSII 1140
AGILLLLALV AILWKLGFFK RKYEKMTKNP DEIDETTELS S 1181 
Gene Ontology
 GO:0045178; C:basal part of cell; IEA:Compara.
 GO:0009986; C:cell surface; IDA:BHF-UCL.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0008305; C:integrin complex; TAS:ProtInc.
 GO:0005518; F:collagen binding; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007160; P:cell-matrix adhesion; TAS:ProtInc.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0009887; P:organ morphogenesis; TAS:ProtInc.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR013517; FG-GAP.
 IPR013519; Int_alpha_beta-p.
 IPR000413; Integrin_alpha.
 IPR013649; Integrin_alpha-2.
 IPR018184; Integrin_alpha_C_CS.
 IPR002035; VWF_A. 
Pfam
 PF01839; FG-GAP
 PF08441; Integrin_alpha2
 PF00092; VWA 
SMART
 SM00191; Int_alpha
 SM00327; VWA 
PROSITE
 PS51470; FG_GAP
 PS00242; INTEGRIN_ALPHA
 PS50234; VWFA 
PRINTS
 PR01185; INTEGRINA.