UniProt Accession

 QPCT_HUMAN; Q16769; Q16770; Q3KRG6; Q53TR4 

Genbank Protein ID

 X71125; X67731; AK290605; AC007391; CH471053; CH471053; CH471053; BC036721; BC047756 

Genbank Nucleotide ID

 CAA50438.1; CAA47961.1; BAF83294.1; AAY14804.1; EAX00392.1; EAX00394.1; EAX00396.1; AAH36721.1; AAH47756.1 

Protein Name

 Glutaminyl-peptide cyclotransferase 

Protein Synonyms/Alias

 Glutaminyl cyclase; QC; sQC; Glutaminyl-tRNA cyclotransferase; Glutamyl cyclase; EC 

Gene Name

 QPCT 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
222	GSRHLAAKMASTPHP	ubiquitination	[1]
285	LHELGLLKDHSLEGR	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. 

Sequence Annotation

 ACT_SITE 201 201 Proton acceptor.
 ACT_SITE 248 248 Proton acceptor.
 METAL 159 159 Zinc; catalytic.
 METAL 202 202 Zinc; catalytic.
 METAL 330 330 Zinc; catalytic.
 CARBOHYD 49 49 N-linked (GlcNAc...).
 CARBOHYD 296 296 N-linked (GlcNAc...) (Potential).
 DISULFID 139 164  

Keyword

 3D-structure; Acyltransferase; Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Metal-binding; Polymorphism; Reference proteome; Secreted; Signal; Transferase; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 361 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0016603; F:glutaminyl-peptide cyclotransferase activity; IDA:UniProtKB.
 GO:0008233; F:peptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IDA:UniProtKB.
 GO:0017186; P:peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase; IDA:UniProtKB.
 GO:0006508; P:proteolysis; IEA:InterPro. 

Interpro

 IPR007484; Peptidase_M28. 

Pfam

 PF04389; Peptidase_M28 

SMART

  

PROSITE

  

PRINTS