| Tag | Content |
|---|
| CPLM ID | CPLM-012290 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription factor E2F2 |
Protein Synonyms/Alias | E2F-2 |
Gene Name | E2F2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 88 | GRLPAKRKLDLEGIG | ubiquitination | [1] | | 187 | QLIRKKAKNNIQWVG | ubiquitination | [1] | | 206 | EDPTRPGKQQQLGQE | ubiquitination | [1] | | 236 | QSCSLSFKHLTEDKA | ubiquitination | [1] | | 262 | IRAVGNFKEQTVIAV | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. |
Sequence Annotation | DNA_BIND 107 196 Potential.
REGION 65 105 Cyclin A/CDK2 binding (Potential).
REGION 155 176 Leucine-zipper.
REGION 197 289 Dimerization (Potential).
REGION 359 437 Transactivation (Potential).
REGION 410 427 Retinoblastoma protein binding
MOTIF 160 196 DEF box. |
Keyword | 3D-structure; Activator; Cell cycle; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 437 AA |
Protein Sequence | MLQGPRALAS AAGQTPKVVP AMSPTELWPS GLSSPQLCPA TATYYTPLYP QTAPPAAAPG 60
TCLDATPHGP EGQVVRCLPA GRLPAKRKLD LEGIGRPVVP EFPTPKGKCI RVDGLPSPKT 120
PKSPGEKTRY DTSLGLLTKK FIYLLSESED GVLDLNWAAE VLDVQKRRIY DITNVLEGIQ 180
LIRKKAKNNI QWVGRGMFED PTRPGKQQQL GQELKELMNT EQALDQLIQS CSLSFKHLTE 240
DKANKRLAYV TYQDIRAVGN FKEQTVIAVK APPQTRLEVP DRTEDNLQIY LKSTQGPIEV 300
YLCPEEVQEP DSPSEEPLPS TSTLCPSPDS AQPSSSTDPS IMEPTASSVP APAPTPQQAP 360
PPPSLVPLEA TDSLLELPHP LLQQTEDQFL SPTLACSSPL ISFSPSLDQD DYLWGLEAGE 420
GISDLFDSYD LGDLLIN 437 |
Gene Ontology | GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0005667; C:transcription factor complex; IEA:InterPro. GO:0001047; F:core promoter binding; IDA:UniProtKB. GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:ProtInc. GO:0006915; P:apoptotic process; IEA:Compara. GO:0000278; P:mitotic cell cycle; TAS:Reactome. GO:0051726; P:regulation of cell cycle; IEA:Compara. GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |