UniProt Accession

 MGST3_HUMAN; O14880; B2R592; Q6ICN4 

Genbank Protein ID

 AF026977; CR450359; AY388493; AK312103; AL451074; CH471067; BC000505; BC003034; BC005964 

Genbank Nucleotide ID

 AAB82609.1; CAG29355.1; AAQ81301.1; BAG35039.1; CAH74057.1; EAW90752.1; AAH00505.1; AAH03034.1; AAH05964.1 

Protein Name

 Microsomal glutathione S-transferase 3 

Protein Synonyms/Alias

 Microsomal GST-3; Microsomal GST-III 

Gene Name

 MGST3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
111	YYTGEPSKRSRGALG	ubiquitination	[1, 2, 3]
149	SGLGSGPKCCH****	ubiquitination	[4, 5]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Also functions as a glutathione peroxidase. 

Sequence Annotation

 LIPID 150 150 S-palmitoyl cysteine.
 LIPID 151 151 S-palmitoyl cysteine.  

Keyword

 Complete proteome; Endoplasmic reticulum; Lipoprotein; Membrane; Microsome; Palmitate; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 152 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005635; C:nuclear envelope; IBA:RefGenome.
 GO:0004602; F:glutathione peroxidase activity; IBA:RefGenome.
 GO:0004364; F:glutathione transferase activity; IBA:RefGenome.
 GO:0006629; P:lipid metabolic process; TAS:ProtInc.
 GO:0007165; P:signal transduction; TAS:ProtInc.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 

Interpro

 IPR023352; MAPEG-like_dom.
 IPR001129; Membr-assoc_MAPEG. 

Pfam

 PF01124; MAPEG 

SMART

  

PROSITE

  

PRINTS