UniProt Accession

 TACD2_HUMAN; P09758; Q15658; Q6FG48; Q7Z7Q4; Q96QD2 

Genbank Protein ID

 X13425; J04152; X77753; X77754; BT007255; CR542260; AL035411; BC009409 

Genbank Nucleotide ID

 CAA31781.1; AAA52505.1; CAA54799.1; CAA54801.1; AAP35919.1; CAG47056.1; CAB72325.1; AAH09409.1 

Protein Name

 Tumor-associated calcium signal transducer 2 

Protein Synonyms/Alias

 Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733-1 

Gene Name

 TACSTD2 

Gene Synonyms/Alias

 GA733-1; M1S1; TROP2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
312	KYKKVEIKELGELRK	ubiquitination	[1]
319	KELGELRKEPSL***	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May function as a growth factor receptor. 

Sequence Annotation

 DOMAIN 70 145 Thyroglobulin type-1.
 CARBOHYD 33 33 N-linked (GlcNAc...) (Potential).
 CARBOHYD 120 120 N-linked (GlcNAc...) (Potential).
 CARBOHYD 168 168 N-linked (GlcNAc...) (Potential).
 CARBOHYD 208 208 N-linked (GlcNAc...) (Potential).
 DISULFID 73 108 By similarity.
 DISULFID 119 125 By similarity.
 DISULFID 127 145 By similarity.  

Keyword

 Amyloid; Amyloidosis; Complete proteome; Corneal dystrophy; Disulfide bond; Glycoprotein; Membrane; Polymorphism; Reference proteome; Sensory transduction; Signal; Transmembrane; Transmembrane helix; Tumor antigen; Vision. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 323 AA 

Protein Sequence

Gene Ontology

 GO:0009925; C:basal plasma membrane; ISS:UniProtKB.
 GO:0005829; C:cytosol; TAS:ProtInc.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0016328; C:lateral plasma membrane; ISS:UniProtKB.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
 GO:0090191; P:negative regulation of branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
 GO:0010633; P:negative regulation of epithelial cell migration; ISS:UniProtKB.
 GO:1900028; P:negative regulation of ruffle assembly; ISS:UniProtKB.
 GO:0051497; P:negative regulation of stress fiber assembly; ISS:UniProtKB.
 GO:1900025; P:negative regulation of substrate adhesion-dependent cell spreading; ISS:UniProtKB.
 GO:0050678; P:regulation of epithelial cell proliferation; IEA:Compara.
 GO:0060675; P:ureteric bud morphogenesis; IEA:Compara.
 GO:0007601; P:visual perception; TAS:ProtInc. 

Interpro

 IPR000716; Thyroglobulin_1. 

Pfam

 PF00086; Thyroglobulin_1 

SMART

 SM00211; TY 

PROSITE

 PS00484; THYROGLOBULIN_1_1
 PS51162; THYROGLOBULIN_1_2 

PRINTS