CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021603
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 p53-induced protein with a death domain 
Protein Synonyms/Alias
 Leucine-rich repeat and death domain-containing protein 
Gene Name
 PIDD 
Gene Synonyms/Alias
 LRDD 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
98CLRSLVLKGGQRRDTubiquitination[1]
639LQCLPRNKVDATLRRubiquitination[2]
743AEAARQRKGADALWMubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways. 
Sequence Annotation
 REPEAT 126 147 LRR 1.
 REPEAT 149 171 LRR 2.
 REPEAT 172 194 LRR 3.
 REPEAT 195 216 LRR 4.
 REPEAT 218 240 LRR 5.
 REPEAT 241 263 LRR 6.
 REPEAT 264 285 LRR 7.
 DOMAIN 315 422 ZU5 1.
 DOMAIN 423 452 Peptidase S68.
 DOMAIN 453 565 ZU5 2.
 DOMAIN 788 873 Death.
 REGION 580 716 UPA domain (By similarity).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 299 299 Phosphoserine.
 MOD_RES 305 305 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Direct protein sequencing; Leucine-rich repeat; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 910 AA 
Protein Sequence
MAATVEGPEL EAAAAAGDAS EDSDAGSRAL PFLGGNRLSL DLYPGGCQQL LHLCVQQPLQ 60
LLQVEFLRLS THEDPQLLEA TLAQLPQSLS CLRSLVLKGG QRRDTLGACL RGALTNLPAG 120
LSGLAHLAHL DLSFNSLETL PACVLQMRGL GALLLSHNCL SELPEALGAL PALTFLTVTH 180
NRLQTLPPAL GALSTLQRLD LSQNLLDTLP PEIGGLGSLL ELNLASNRLQ SLPASLAGLR 240
SLRLLVLHSN LLASVPADLA RLPLLTRLDL RDNQLRDLPP ELLDAPFVRL QGNPLGEASP 300
DAPSSPVAAL IPEMPRLFLT SDLDSFPVTP QGCSVTLACG VRLQFPAGAT ATPITIRYRL 360
LLPEPGLVPL GPHDALLSHV LELQPHGVAF QQDVGLWLLF TPPQARRCRE VVVRTRNDNS 420
WGDLETYLEE EAPQRLWAHC QVPHFSWFLV VSRPVSNACL VPPEGTLLCS SGHPGVKVIF 480
PPGATEEPRR VSMQVVRMAG RELQALLGEP EAAVSPLLCL SQSGPPSFLQ PVTVQLPLPS 540
GITGLSLDRS RLHLLYWAPP AATWDDITAQ VVLELTHLYA RFQVTHFSWY WLWYTTKNCV 600
GGLARKAWER LRLHRVNLIA LQRRRDPEQV LLQCLPRNKV DATLRRLLER YRGPEPSDTV 660
EMFEGEEFFA AFERGIDVDA DRPDCVEGRI CFVFYSHLKN VKEVYVTTTL DREAQAVRGQ 720
VSFYRGAVPV RVPEEAEAAR QRKGADALWM ATLPIKLPRL RGSEGPRRGA GLSLAPLNLG 780
DAETGFLTQS NLLSVAGRLG LDWPAVALHL GVSYREVQRI RHEFRDDLDE QIRHMLFSWA 840
ERQAGQPGAV GLLVQALEQS DRQDVAEEVR AVLELGRRKY QDSIRRMGLA PKDPALPGSS 900
APQPPEPAQA 910 
Gene Ontology
 GO:0005737; C:cytoplasm; IMP:UniProtKB.
 GO:0005634; C:nucleus; IMP:UniProtKB.
 GO:0005123; F:death receptor binding; TAS:ProtInc.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IMP:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB. 
Interpro
 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR019502; Peptidase_S68_pidd.
 IPR000906; ZU5. 
Pfam
 PF00531; Death
 PF00560; LRR_1
 PF10461; Peptidase_S68
 PF00791; ZU5 
SMART
 SM00005; DEATH
 SM00369; LRR_TYP 
PROSITE
 PS50017; DEATH_DOMAIN
 PS51450; LRR
 PS51145; ZU5 
PRINTS