UniProt Accession

 PUR6_MOUSE; Q9DCL9; Q9CQ38 

Genbank Protein ID

 AK002669; AK010462; AK012118; AK146722; AK159398; AK166264; CH466524; BC018153; BC052691 

Genbank Nucleotide ID

 BAB22273.1; BAB26957.1; BAB28044.1; BAE27385.1; BAE35051.1; BAE38669.1; EDL37918.1; AAH18153.1; AAH52691.1 

Protein Name

 Multifunctional protein ADE2 

Protein Synonyms/Alias

 Phosphoribosylaminoimidazole-succinocarboxamide synthase; SAICAR synthetase; Phosphoribosylaminoimidazole carboxylase; AIR carboxylase; AIRC 

Gene Name

 Paics 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
36	GRVLLQSKDQITAGN	ubiquitination	[1]
53	RKNHLEGKAAISNKI	ubiquitination	[1]
110	IATGSFLKRNPGVQE	acetylation	[2, 3]
110	IATGSFLKRNPGVQE	succinylation	[3]
110	IATGSFLKRNPGVQE	ubiquitination	[1]
120	PGVQEGYKFYPPKVE	ubiquitination	[1]
235	KQSYRDLKEVTPEGL	ubiquitination	[1]
247	EGLQMVKKNFEWVAD	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

 REGION 2 260 SAICAR synthetase.
 REGION 261 425 AIR carboxylase.
 REGION 261 266 Linker (By similarity).
 REGION 267 425 AIR carboxylase (By similarity).
 ACT_SITE 101 101 For SAICAR synthetase activity (By
 ACT_SITE 107 107 For SAICAR synthetase activity (By
 ACT_SITE 215 215 For SAICAR synthetase activity (By
 ACT_SITE 303 303 For AIR carboxylase activity (By
 ACT_SITE 332 332 For AIR carboxylase activity (By
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 22 22 Phosphotyrosine.
 MOD_RES 107 107 Phosphoserine (By similarity).
 MOD_RES 238 238 Phosphothreonine (By similarity).
 MOD_RES 247 247 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Decarboxylase; Ligase; Lyase; Multifunctional enzyme; Nucleotide-binding; Phosphoprotein; Purine biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 425 AA 

Protein Sequence

Gene Ontology

 GO:0034023; F:5-(carboxyamino)imidazole ribonucleotide mutase activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004638; F:phosphoribosylaminoimidazole carboxylase activity; IEA:EC.
 GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:EC.
 GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR013816; ATP_grasp_subdomain_2.
 IPR000031; N5-CAIR_Mutase_PurE_dom.
 IPR001636; SAICAR_synth.
 IPR018236; SAICAR_synthetase_CS. 

Pfam

 PF00731; AIRC
 PF01259; SAICAR_synt 

SMART

 SM01001; AIRC 

PROSITE

 PS01057; SAICAR_SYNTHETASE_1
 PS01058; SAICAR_SYNTHETASE_2 

PRINTS