CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015334
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 773 
Protein Synonyms/Alias
 Zinc finger protein 419B 
Gene Name
 ZNF773 
Gene Synonyms/Alias
 ZNF419B 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
217QRLHTGEKPYECSECubiquitination[1]
343CGKFYSHKSSLINHWubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 15 86 KRAB.
 ZN_FING 191 213 C2H2-type 1.
 ZN_FING 219 241 C2H2-type 2.
 ZN_FING 247 269 C2H2-type 3.
 ZN_FING 275 297 C2H2-type 4.
 ZN_FING 303 325 C2H2-type 5.
 ZN_FING 331 353 C2H2-type 6.
 ZN_FING 359 381 C2H2-type 7.
 ZN_FING 387 409 C2H2-type 8.
 ZN_FING 415 437 C2H2-type 9.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 442 AA 
Protein Sequence
MAAATLRDPA QQGYVTFEDV AVYFSQEEWR LLDDAQRLLY RNVMLENFTL LASLGLASSK 60
THEITQLESW EEPFMPAWEV VTSAILRGSW QGAKAEAAAE QSASVEVPSS NVQQHQKQHC 120
GEKPLKRQEG RVPVLRSCRV HLSEKSLQSR EVGKDLLTSS GVLKHQVTHT GEKSHRSSKS 180
REAFHAGKRH YKCSECGKAF GQKYLLVQHQ RLHTGEKPYE CSECGKLFSH KSNLFIHQIV 240
HTGERPYGCS DCGKSFSRNA DLIQHQRVHT GEKPFTCSEC GKAFRHNSTL VQHHRIHTGV 300
RPYECSECGK LFSFNSSLMK HQRVHTGERP YKCSECGKFY SHKSSLINHW RVHTGERPYE 360
CSECGKFFSQ SSSLMQHRKV HTGEKPFKCN ECGRFFSENS SLVKHQRVHT GAKPYECREC 420
GKFFRHSSSL VKHRRIHTGE IQ 442 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS