| Tag | Content |
|---|
| CPLM ID | CPLM-012630 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ephrin-B3 |
Protein Synonyms/Alias | EPH-related receptor transmembrane ligand ELK-L3; EPH-related receptor tyrosine kinase ligand 8; LERK-8 |
Gene Name | EFNB3 |
Gene Synonyms/Alias | EPLG8; LERK8 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 339 | SPPNIYYKV****** | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). |
Sequence Annotation | DOMAIN 28 167 Ephrin RBD.
MOTIF 338 340 PDZ-binding (Potential).
CARBOHYD 210 210 N-linked (GlcNAc...) (Potential).
DISULFID 62 104 By similarity.
DISULFID 92 156 By similarity. |
Keyword | Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; Disulfide bond; Glycoprotein; Host-virus interaction; Membrane; Neurogenesis; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 340 AA |
Protein Sequence | MGPPHSGPGG VRVGALLLLG VLGLVSGLSL EPVYWNSANK RFQAEGGYVL YPQIGDRLDL 60
LCPRARPPGP HSSPNYEFYK LYLVGGAQGR RCEAPPAPNL LLTCDRPDLD LRFTIKFQEY 120
SPNLWGHEFR SHHDYYIIAT SDGTREGLES LQGGVCLTRG MKVLLRVGQS PRGGAVPRKP 180
VSEMPMERDR GAAHSLEPGK ENLPGDPTSN ATSRGAEGPL PPPSMPAVAG AAGGLALLLL 240
GVAGAGGAMC WRRRRAKPSE SRHPGPGSFG RGGSLGLGGG GGMGPREAEP GELGIALRGG 300
GAADPPFCPH YEKVSGDYGH PVYIVQDGPP QSPPNIYYKV 340 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0046875; F:ephrin receptor binding; IDA:MGI. GO:0005005; F:transmembrane-ephrin receptor activity; TAS:ProtInc. GO:0007628; P:adult walking behavior; IEA:Compara. GO:0016198; P:axon choice point recognition; IEA:Compara. GO:0007267; P:cell-cell signaling; TAS:ProtInc. GO:0007399; P:nervous system development; TAS:ProtInc. GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. |
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