CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025936
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Probable E3 ubiquitin-protein ligase TRIM8 
Protein Synonyms/Alias
  
Gene Name
 TRIM8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
45CIGEAWAKDSGLVRCubiquitination[1]
70PGLEKNLKLTNIVEKubiquitination[1]
194NEIRMLMKQQDRLEEubiquitination[1]
212DIEDQLYKLESDKRLubiquitination[1]
237EVRLQYEKLHQLLDEubiquitination[1]
255QTVEVLDKAQAKFCSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 550 AA 
Protein Sequence
MAENWKNCFE EELICPICLH VFVEPVQLPC KHNFCRGCIG EAWAKDSGLV RCPECNQAYN 60
QKPGLEKNLK LTNIVEKFNA LHVEKPPAAL HCVFCRRGPP LPAQKVCLRC EAPCCQSHVQ 120
THLQQPSTAR GHLLVEADDV RAWSCPQHNA YRLYHCEAEQ VAVCQYCCYY SGAHQGHSVC 180
DVEIRRNEIR MLMKQQDRLE EREQDIEDQL YKLESDKRLV EEKVNQLKEE VRLQYEKLHQ 240
LLDEDLRQTV EVLDKAQAKF CSENAAQALH LGERMQEAKK LLGSLQLLFD KTEDVSFMKN 300
TKSVKILMDR TQTCTSSSLS PTKIGHLNSK LFLNEVAKKE KQLRKMLEGP FSTPVPFLQS 360
VPLYPCGVSS SGAEKRKHST AFPEASFLET SSGPVGGQYG AAGTASGEGQ SGQPLGPCSS 420
TQHLVALPGG AQPVHSSPVF PPSQYPNGSA AQQPMLPQYG GRKILVCSVD NCYCSSVANH 480
GGHQPYPRSG HFPWTVPSQE YSHPLPPTPS VPQSLPSLAV RDWLDASQQP GHQDFYRVYG 540
QPSTKHYVTS 550 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR018957; Znf_C3HC4_RING-type.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00097; zf-C3HC4 
SMART
 SM00184; RING 
PROSITE
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS