UniProt Accession

 ELAV2_HUMAN; Q12926; D3DRK3; Q13235; Q59G15; Q8NEM4; Q9H1Q8 

Genbank Protein ID

 U12431; U29943; AB209294; AL161628; AL445623; AL161628; CH471071; CH471071; BC030692 

Genbank Nucleotide ID

 AAA69698.1; AAA70417.1; BAD92531.1; CAI13376.1; CAI13376.1; CAC22160.1; EAW58581.1; EAW58582.1; AAH30692.1 

Protein Name

 ELAV-like protein 2 

Protein Synonyms/Alias

 ELAV-like neuronal protein 1; Hu-antigen B; HuB; Nervous system-specific RNA-binding protein Hel-N1 

Gene Name

 ELAVL2 

Gene Synonyms/Alias

 HUB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
74	SCKLVRDKITGQSLG	ubiquitination	[1]
95	IDPKDAEKAINTLNG	ubiquitination	[1]
209	FANNPSQKTNQAILS	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

 Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR. 

Sequence Annotation

 DOMAIN 39 117 RRM 1.
 DOMAIN 125 205 RRM 2.
 DOMAIN 276 354 RRM 3.
 MOD_RES 221 221 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Repeat; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 359 AA 

Protein Sequence

Gene Ontology

 GO:0003730; F:mRNA 3'-UTR binding; TAS:ProtInc.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; TAS:ProtInc. 

Interpro

 IPR006548; ELAD_HUD_SF.
 IPR002343; Hud_Sxl_RNA.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS

 PR00961; HUDSXLRNA.