CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002613
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bifunctional protein FolC 
Protein Synonyms/Alias
 Folylpolyglutamate synthase; Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase; Dihydrofolate synthase 
Gene Name
 folC 
Gene Synonyms/Alias
 dedC; b2315; JW2312 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
46AARLGVLKPAPFVFTacetylation[1]
216IADVAQEKGALLQRRacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Conversion of folates to polyglutamate derivatives. 
Sequence Annotation
 NP_BIND 56 62 ATP (By similarity).
 DISULFID 354 401 Probable.  
Keyword
 3D-structure; ATP-binding; Complete proteome; Disulfide bond; Folate biosynthesis; Ligase; Multifunctional enzyme; Nucleotide-binding; One-carbon metabolism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 422 AA 
Protein Sequence
MIIKRTPQAA SPLASWLSYL ENLHSKTIDL GLERVSLVAA RLGVLKPAPF VFTVAGTNGK 60
GTTCRTLESI LMAAGYKVGV YSSPHLVRYT ERVRVQGQEL PESAHTASFA EIESARGDIS 120
LTYFEYGTLS ALWLFKQAQL DVVILEVGLG GRLDATNIVD ADVAVVTSIA LDHTDWLGPD 180
RESIGREKAG IFRSEKPAIV GEPEMPSTIA DVAQEKGALL QRRGVEWNYS VTDHDWAFSD 240
AHGTLENLPL PLVPQPNAAT ALAALRASGL EVSENAIRDG IASAILPGRF QIVSESPRVI 300
FDVAHNPHAA EYLTGRMKAL PKNGRVLAVI GMLHDKDIAG TLAWLKSVVD DWYCAPLEGP 360
RGATAEQLLE HLGNGKSFDS VAQAWDAAMA DAKAEDTVLV CGSFHTVAHV MEVIDARRSG 420
GK 422 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:EcoCyc.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008841; F:dihydrofolate synthase activity; IDA:EcoCyc.
 GO:0004326; F:tetrahydrofolylpolyglutamate synthase activity; IDA:EcoCyc.
 GO:0009257; P:10-formyltetrahydrofolate biosynthetic process; IGI:EcoCyc.
 GO:0046656; P:folic acid biosynthetic process; IGI:EcoCyc.
 GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. 
Interpro
 IPR001645; Folylpolyglutamate_synth.
 IPR018109; Folylpolyglutamate_synth_CS.
 IPR004101; Mur_ligase_C.
 IPR013221; Mur_ligase_cen. 
Pfam
 PF02875; Mur_ligase_C
 PF08245; Mur_ligase_M 
SMART
  
PROSITE
 PS01011; FOLYLPOLYGLU_SYNT_1
 PS01012; FOLYLPOLYGLU_SYNT_2 
PRINTS