| Tag | Content |
|---|
| CPLM ID | CPLM-010359 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase |
Protein Synonyms/Alias | Polymyxin resistance protein PmrF; Undecaprenyl-phosphate Ara4FN transferase; Ara4FN transferase |
Gene Name | arnC |
Gene Synonyms/Alias | pmrF; yfbF; b2254; JW2248 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 319 | QVIRPSSKENE**** | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. |
Sequence Annotation | |
Keyword | Antibiotic resistance; Cell inner membrane; Cell membrane; Complete proteome; Glycosyltransferase; Lipid A biosynthesis; Lipid biosynthesis; Lipid metabolism; Lipopolysaccharide biosynthesis; Membrane; Reference proteome; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 322 AA |
Protein Sequence | MFEIHPVKKV SVVIPVYNEQ ESLPELIRRT TTACESLGKE YEILLIDDGS SDNSAHMLVE 60
ASQAENSHIV SILLNRNYGQ HSAIMAGFSH VTGDLIITLD ADLQNPPEEI PRLVAKADEG 120
YDVVGTVRQN RQDSWFRKTA SKMINRLIQR TTGKAMGDYG CMLRAYRRHI VDAMLHCHER 180
STFIPILANI FARRAIEIPV HHAEREFGES KYSFMRLINL MYDLVTCLTT TPLRMLSLLG 240
SIIAIGGFSI AVLLVILRLT FGPQWAAEGV FMLFAVLFTF IGAQFIGMGL LGEYIGRIYT 300
DVRARPRYFV QQVIRPSSKE NE 322 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016020; C:membrane; IDA:EcoCyc. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IDA:EcoCyc. GO:0016757; F:transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW. GO:0036108; P:4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process; IEA:UniProtKB-UniPathway. GO:0009245; P:lipid A biosynthetic process; IEA:HAMAP. GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW. |
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