CPLM-017828

Genbank Nucleotide ID

Bone marrow stromal antigen 2

Protein Synonyms/Alias

BST-2; HM1.24 antigen; CD317

Mus musculus (Mouse)

Position	Peptide	Type	References
110	LQESLEKKVSQALEQ	ubiquitination	[1]
122	LEQQARIKELENEVT	acetylation	[2]
130	ELENEVTKLNQELEN	ubiquitination	[1]

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]

Functional Description

IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells.

LIPID 152 152 GPI-anchor amidated serine (Potential).
CARBOHYD 70 70 N-linked (GlcNAc...).
CARBOHYD 94 94 N-linked (GlcNAc...); atypical.
CARBOHYD 97 97 N-linked (GlcNAc...) (Potential).
DISULFID 58 58 Interchain.
DISULFID 68 68 Interchain.
DISULFID 96 96 Interchain.

3D-structure; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Disulfide bond; Endosome; Glycoprotein; Golgi apparatus; GPI-anchor; Immunity; Innate immunity; Lipoprotein; Membrane; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
GO:0008191; F:metalloendopeptidase inhibitor activity; ISS:UniProtKB.
GO:0004871; F:signal transducer activity; IEA:Compara.
GO:0051607; P:defense response to virus; IEA:Compara.
GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.
GO:1901253; P:negative regulation of egress of virus within host cell; IDA:UniProtKB.
GO:0002737; P:negative regulation of plasmacytoid dendritic cell cytokine production; ISS:UniProtKB.
GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.
GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
GO:0035456; P:response to interferon-beta; IDA:UniProtKB.
GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
GO:0009615; P:response to virus; IDA:UniProtKB.