| Tag | Content |
|---|
| CPLM ID | CPLM-020023 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Calcium uptake protein 1, mitochondrial |
Protein Synonyms/Alias | Atopy-related autoantigen CALC; ara CALC; Calcium-binding atopy-related autoantigen 1; Hom s 4 |
Gene Name | MICU1 |
Gene Synonyms/Alias | CALC; CBARA1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 294 | LKGKLTIKNFLEFQR | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. Acts as a gatekeeper that senses calcium level via its EF- hand domains and sets a threshold for mitochondrial calcium uptake by MCU, thereby preventing mitochondrial calcium overload. Regulates glucose-dependent insulin secretion in pancreatic beta- cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. |
Sequence Annotation | DOMAIN 218 253 EF-hand 1.
DOMAIN 408 443 EF-hand 2. |
Keyword | Allergen; Alternative splicing; Calcium; Calcium transport; Complete proteome; Ion transport; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; Transit peptide; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 476 AA |
Protein Sequence | MFRLNSLSAL AELAVGSRWY HGGSQPIQIR RRLMMVAFLG ASAVTASTGL LWKRAHAESP 60
PCVDNLKSDI GDKGKNKDEG DVCNHEKKTA DLAPHPEEKK KKRSGFRDRK VMEYENRIRA 120
YSTPDKIFRY FATLKVISEP GEAEVFMTPE DFVRSITPNE KQPEHLGLDQ YIIKRFDGKK 180
ISQEREKFAD EGSIFYTLGE CGLISFSDYI FLTTVLSTPQ RNFEIAFKMF DLNGDGEVDM 240
EEFEQVQSII RSQTSMGMRH RDRPTTGNTL KSGLCSALTT YFFGADLKGK LTIKNFLEFQ 300
RKLQHDVLKL EFERHDPVDG RITERQFGGM LLAYSGVQSK KLTAMQRQLK KHFKEGKGLT 360
FQEVENFFTF LKNINDVDTA LSFYHMAGAS LDKVTMQQVA RTVAKVELSD HVCDVVFALF 420
DCDGNGELSN KEFVSIMKQR LMRGLEKPKD MGFTRLMQAM WKCAQETAWD FALPKQ 476 |
Gene Ontology | GO:0034704; C:calcium channel complex; ISS:UniProtKB. GO:0032592; C:integral to mitochondrial membrane; IDA:UniProtKB. GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB. GO:0005509; F:calcium ion binding; IDA:UniProtKB. GO:0070509; P:calcium ion import; IDA:UniProtKB. GO:0006952; P:defense response; TAS:ProtInc. GO:0051560; P:mitochondrial calcium ion homeostasis; IMP:UniProtKB. GO:0006851; P:mitochondrial calcium ion transport; IMP:UniProtKB. |
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