CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016412
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Band 4.1-like protein 5 
Protein Synonyms/Alias
  
Gene Name
 Epb41l5 
Gene Synonyms/Alias
 Epb4.1l5; Kiaa1548 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
40IPAAGDAKSIITCRVubiquitination[1]
223AETNYLNKAKWLEMYubiquitination[1]
350SRFRYSGKTEYQTTKubiquitination[1]
383SRRTLQMKASTTQPEubiquitination[1]
502KAECETLKDDTEKLKubiquitination[1]
507TLKDDTEKLKQLETEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells (By similarity). 
Sequence Annotation
 DOMAIN 43 327 FERM.  
Keyword
 Alternative splicing; Cell junction; Complete proteome; Cytoplasm; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 731 AA 
Protein Sequence
MLSFLRRTLG RRSMRKHAEK ERLREAQRAA THIPAAGDAK SIITCRVSLL DGTDVSVDLP 60
KKAKGQELFD QIMYHLDLIE SDYFGLRFMD SAQVAHWLDG TKSIKKQVKI GSPYCLHLRV 120
KFYSSEPNNL REELTRYLFV LQLKQDILSG KLECPFDTAV QLAAYNLQAE LGDYDLAEHS 180
PELVSEFRFV PIQTEEMELA IFEKWKEYRG QTPAQAETNY LNKAKWLEMY GVDMHVVKAR 240
DGNDYSLGLT PTGVLVFEGE TKIGLFFWPK ITRLDFKKNK LTLVVVEDDD QGKEQEHTFV 300
FRLDHPKACK HLWKCAVEHH AFFRLRGPVQ KSSHRSGFIR LGSRFRYSGK TEYQTTKTNK 360
ARRSTSFERR PSKRYSRRTL QMKASTTQPE DLGVLNASAQ KSDSQQAWGV MSPVPVTSSS 420
SCGAVQVEIE NLPQTSATEQ HDRKCLPLSV DLLNSPDLLE TTIGDVTRTS ETSAPFPAPD 480
TINVATRSNE LEEFKAECET LKDDTEKLKQ LETEQTILPS LRPTIDINVN SQEEVVKLTE 540
KCLNNAIENP ALNAVKVPPD FKSNILKAQV EAVHKVTRED SLLTHKNASV QDAATNSTAF 600
NENDVPVCKD SLTPVHGTAA DSASVLKDAT DELDALLLSL TENLMDHTVT PQVSSPSMIT 660
PRWIIPQSAT ISNGLAGYGA SLAGTDECSQ KDGFSLISPP APFLVDAVTS SAPPLPEDST 720
LKQKCLLTTE L 731 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0019898; C:extrinsic to membrane; IEA:InterPro.
 GO:0005925; C:focal adhesion; IDA:MGI.
 GO:0032587; C:ruffle membrane; IDA:MGI.
 GO:0031032; P:actomyosin structure organization; IDA:MGI.
 GO:0003383; P:apical constriction; IDA:MGI.
 GO:0048319; P:axial mesoderm morphogenesis; IMP:MGI.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; IDA:MGI.
 GO:0007398; P:ectoderm development; IMP:MGI.
 GO:0048617; P:embryonic foregut morphogenesis; IMP:MGI.
 GO:0007492; P:endoderm development; IMP:MGI.
 GO:0001837; P:epithelial to mesenchymal transition; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0070986; P:left/right axis specification; IMP:MGI.
 GO:0007509; P:mesoderm migration involved in gastrulation; IMP:MGI.
 GO:0022408; P:negative regulation of cell-cell adhesion; IMP:MGI.
 GO:0032091; P:negative regulation of protein binding; IDA:MGI.
 GO:0001839; P:neural plate morphogenesis; IMP:MGI.
 GO:0048339; P:paraxial mesoderm development; IMP:MGI.
 GO:0010634; P:positive regulation of epithelial cell migration; IMP:MGI.
 GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IMP:MGI.
 GO:0051894; P:positive regulation of focal adhesion assembly; IMP:MGI.
 GO:0032092; P:positive regulation of protein binding; IDA:MGI.
 GO:0010608; P:posttranscriptional regulation of gene expression; IMP:MGI.
 GO:0070201; P:regulation of establishment of protein localization; IDA:MGI.
 GO:0032525; P:somite rostral/caudal axis specification; IMP:MGI.
 GO:0006931; P:substrate-dependent cell migration, cell attachment to substrate; IMP:MGI.
 GO:0009826; P:unidimensional cell growth; IDA:MGI. 
Interpro
 IPR019749; Band_41_domain.
 IPR019750; Band_41_fam.
 IPR000798; Ez/rad/moesin_like.
 IPR014847; FERM-adjacent.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR019747; FERM_CS.
 IPR000299; FERM_domain.
 IPR018979; FERM_N.
 IPR018980; FERM_PH-like_C.
 IPR011993; PH_like_dom. 
Pfam
 PF08736; FA
 PF09380; FERM_C
 PF00373; FERM_M
 PF09379; FERM_N 
SMART
 SM00295; B41 
PROSITE
 PS00660; FERM_1
 PS00661; FERM_2
 PS50057; FERM_3 
PRINTS
 PR00935; BAND41.
 PR00661; ERMFAMILY.