CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016332
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat-containing protein 33 
Protein Synonyms/Alias
  
Gene Name
 LRRC33 
Gene Synonyms/Alias
 UNQ3030/PRO9833 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
35AASQGVCKLVGGAADubiquitination[1]
576SLTALPQKAVSEQLSubiquitination[1, 2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
 REPEAT 58 79 LRR 1.
 REPEAT 82 103 LRR 2.
 REPEAT 106 127 LRR 3.
 REPEAT 133 155 LRR 4.
 REPEAT 158 179 LRR 5.
 REPEAT 182 203 LRR 6.
 REPEAT 206 227 LRR 7.
 REPEAT 228 239 LRR 8.
 REPEAT 251 272 LRR 9.
 REPEAT 273 294 LRR 10.
 REPEAT 329 350 LRR 11.
 REPEAT 353 374 LRR 12.
 REPEAT 377 398 LRR 13.
 REPEAT 403 424 LRR 14.
 REPEAT 427 447 LRR 15.
 REPEAT 463 484 LRR 16.
 REPEAT 486 507 LRR 17.
 REPEAT 512 534 LRR 18.
 REPEAT 537 558 LRR 19.
 REPEAT 559 580 LRR 20.
 REPEAT 585 594 LRR 21.
 CARBOHYD 21 21 N-linked (GlcNAc...) (Potential).
 CARBOHYD 74 74 N-linked (GlcNAc...) (Potential).
 CARBOHYD 155 155 N-linked (GlcNAc...) (Potential).
 CARBOHYD 232 232 N-linked (GlcNAc...) (Potential).
 CARBOHYD 292 292 N-linked (GlcNAc...) (Potential).
 CARBOHYD 309 309 N-linked (GlcNAc...) (Potential).
 CARBOHYD 312 312 N-linked (GlcNAc...) (Potential).
 CARBOHYD 408 408 N-linked (GlcNAc...) (Potential).
 CARBOHYD 427 427 N-linked (GlcNAc...) (Potential).
 CARBOHYD 500 500 N-linked (GlcNAc...) (Potential).
 CARBOHYD 622 622 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 692 AA 
Protein Sequence
MELLPLWLCL GFHFLTVGWR NRSGTATAAS QGVCKLVGGA ADCRGQSLAS VPSSLPPHAR 60
MLTLDANPLK TLWNHSLQPY PLLESLSLHS CHLERISRGA FQEQGHLRSL VLGDNCLSEN 120
YEETAAALHA LPGLRRLDLS GNALTEDMAA LMLQNLSSLR SVSLAGNTIM RLDDSVFEGL 180
ERLRELDLQR NYIFEIEGGA FDGLAELRHL NLAFNNLPCI VDFGLTRLRV LNVSYNVLEW 240
FLATGGEAAF ELETLDLSHN QLLFFPLLPQ YSKLRTLLLR DNNMGFYRDL YNTSSPREMV 300
AQFLLVDGNV TNITTVSLWE EFSSSDLADL RFLDMSQNQF QYLPDGFLRK MPSLSHLNLH 360
QNCLMTLHIR EHEPPGALTE LDLSHNQLSE LHLAPGLASC LGSLRLFNLS SNQLLGVPPG 420
LFANARNITT LDMSHNQISL CPLPAASDRV GPPSCVDFRN MASLRSLSLE GCGLGALPDC 480
PFQGTSLTYL DLSSNWGVLN GSLAPLQDVA PMLQVLSLRN MGLHSSFMAL DFSGFGNLRD 540
LDLSGNCLTT FPRFGGSLAL ETLDLRRNSL TALPQKAVSE QLSRGLRTIY LSQNPYDCCG 600
VDGWGALQHG QTVADWAMVT CNLSSKIIRV TELPGGVPRD CKWERLDLGL LYLVLILPSC 660
LTLLVACTVI VLTFKKPLLQ VIKSRCHWSS VY 692 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp. 
Pfam
 PF00560; LRR_1 
SMART
 SM00369; LRR_TYP 
PROSITE
 PS51450; LRR 
PRINTS