CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000780
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Striatin 
Protein Synonyms/Alias
  
Gene Name
 STRN 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
353VKRPNRSKLQDMLANubiquitination[1]
689AHEDRHIKFYDNNTGacetylation[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling. 
Sequence Annotation
 REPEAT 461 500 WD 1.
 REPEAT 514 553 WD 2.
 REPEAT 567 606 WD 3.
 REPEAT 662 701 WD 4.
 REPEAT 704 743 WD 5.
 REPEAT 750 779 WD 6.
 REGION 55 63 Caveolin-binding (Potential).
 REGION 149 166 Calmodulin-binding (Potential).
 MOD_RES 245 245 Phosphoserine.
 MOD_RES 264 264 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Calmodulin-binding; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 780 AA 
Protein Sequence
MDEQAGPGVF FSNNHPGAGG AKGLGPLAEA AAAGDGAAAA GAARAQYSLP GILHFLQHEW 60
ARFEVERAQW EVERAELQAQ IAFLQGERKG QENLKKDLVR RIKMLEYALK QERAKYHKLK 120
YGTELNQGDM KPPSYDSDEG NETEVQPQQN SQLMWKQGRQ LLRQYLQEVG YTDTILDVKS 180
KRVRALLGFS SDVTDREDDK NQDSVVNGTE AEVKETAMIA KSELTDSASV LDNFKFLESA 240
AADFSDEDED DDVDGREKSV IDTSTIVRKK ALPDSGEDRD TKEALKEFDF LVTSEEGDNE 300
SRSAGDGTDW EKEDQCLMPE AWNVDQGVIT KLKEQYKKER KGKKGVKRPN RSKLQDMLAN 360
LRDVDELPSL QPSVGSPSRP SSSRLPEHEI NRADEVEALT FPPSSGKSFI MGADEALESE 420
LGLGELAGLT VANEADSLTY DIANNKDALR KTWNPKFTLR SHFDGIRALA FHPIEPVLIT 480
ASEDHTLKMW NLQKTAPAKK STSLDVEPIY TFRAHKGPVL CVVMSSNGEQ CYSGGTDGLI 540
QGWNTTNPNI DPYDSYDPSV LRGPLLGHTD AVWGLAYSAA HQRLLSCSAD GTLRLWNTTE 600
VAPALSVFND TKELGIPASV DLVSSDPSHM VASFSKGYTS IFNMETQQRI LTLESNVDTT 660
ANSSCQINRV ISHPTLPISI TAHEDRHIKF YDNNTGKLIH SMVAHLEAVT SLAVDPNGLY 720
LMSGSHDCSI RLWNLESKTC IQEFTAHRKK FEESIHDVAF HPSKCYIASA GADALAKVFV 780 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0043025; C:neuronal cell body; ISS:UniProtKB.
 GO:0014069; C:postsynaptic density; ISS:UniProtKB.
 GO:0045211; C:postsynaptic membrane; ISS:UniProtKB.
 GO:0005923; C:tight junction; IDA:UniProtKB.
 GO:0005516; F:calmodulin binding; ISS:UniProtKB.
 GO:0032403; F:protein complex binding; IDA:UniProtKB.
 GO:0051721; F:protein phosphatase 2A binding; IDA:UniProtKB.
 GO:0016358; P:dendrite development; ISS:UniProtKB.
 GO:0007626; P:locomotory behavior; ISS:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; IMP:UniProtKB.
 GO:0070830; P:tight junction assembly; NAS:UniProtKB.
 GO:0016055; P:Wnt receptor signaling pathway; IMP:UniProtKB. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR013258; Striatin_N.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF08232; Striatin
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.