CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016104
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable ATP-dependent RNA helicase DDX10 
Protein Synonyms/Alias
 DEAD box protein 10 
Gene Name
 Ddx10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
556SPAYVSEKMSVLHKSacetylation[1, 2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Putative ATP-dependent RNA helicase (By similarity). 
Sequence Annotation
 DOMAIN 100 274 Helicase ATP-binding.
 DOMAIN 300 449 Helicase C-terminal.
 NP_BIND 89 91 ATP (By similarity).
 NP_BIND 113 120 ATP (By similarity).
 MOTIF 69 97 Q motif.
 MOTIF 222 225 DEAD box.
 BINDING 96 96 ATP (By similarity).
 MOD_RES 4 4 Phosphothreonine (By similarity).
 MOD_RES 540 540 Phosphoserine (By similarity).
 MOD_RES 587 587 Phosphothreonine.
 MOD_RES 783 783 Phosphoserine (By similarity).  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Phosphoprotein; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 875 AA 
Protein Sequence
MGKTVASLGQ GTRPDPVRSF NRWKKKHSHR QHQKKERRKQ LKKPEWQVER EGISRLMQNY 60
EKINVNEITR FSDFPLSKKT LKGLQEAQYR LVTEIQKQTI GLALQGKDVL GAAKTGSGKT 120
LAFLVPVLEA LYRLQWTSTD GLGVLIISPT RELAYQTFEV LRKVGKNHDF SAGLIIGGKD 180
LKHEAERINN INILVCTPGR LLQHMDETIC FHATNLQMLV LDEADRILDM GFADTMNAII 240
ENLPKKRQTL LFSATQTKSV KDLARLSLKD PEYVWVHEKA KYSTPATLEQ NYIICELHQK 300
ISVLFSFLRS HLKKKSIVFF SSCKEVQYLY RVFCRLRPGI SILALHGRQQ QMRRMEVYNE 360
FVRKRAAVLF ATDIAARGLD FPAVNWVLQF DCPEDANTYI HRAGRTARYK EDGEALLILL 420
PSEEQGMVQQ LLQKKVPVKE IKINPEKLID VQKKLESFLA QDQDLKERAQ RCFVSYIRSV 480
YLMKDKEVFN VSKLPITEYA LSLGLAVAPR IRFLQKLEKQ PSTELVKNPV TEAVPPRAPS 540
LPNDEADESP AYVSEKMSVL HKSGERLEET EHRLASGDGD EEQDEETEDE ETEDHLGKAR 600
EPHTESVVSI EEAQKVKEVS VQFLNRDDDD EDGPDADFLT VKRRDVFGLD LKENEALSKK 660
EPSKSSVKKK LTKVAEAKKV MKRSFKVNKK ITFTDEGELV QQWPQIQKCA IKDVEEEDDT 720
GGINLDKAKE RLQEEDKFDK EEYRKKIKAK HRERRLKERE ARREANKRQA KARDEEEAFL 780
DWSDEDDGGF DPSTLPDPDK HRSSEESESE DTNHKMSDTK KKQETRKRNN TEDDDVRPRS 840
RHGKKAKWET VEPLDTGLSL AEDEELVLHL LKSQN 875 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR025313; DUF4217.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000629; RNA-helicase_DEAD-box_CS.
 IPR014014; RNA_helicase_DEAD_Q_motif. 
Pfam
 PF00270; DEAD
 PF13959; DUF4217
 PF00271; Helicase_C 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS00039; DEAD_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 
PRINTS