UniProt Accession

 AP3S2_HUMAN; P59780; B2R677; O09077; O09149; Q53H83; Q99589 

Genbank Protein ID

 X99459; AK312467; AK222698; BC002785; BC010020 

Genbank Nucleotide ID

 CAA67824.1; BAG35374.1; BAD96418.1; AAH02785.1; AAH10020.1 

Protein Name

 AP-3 complex subunit sigma-2 

Protein Synonyms/Alias

 AP-3 complex subunit sigma-3B; Adapter-related protein complex 3 sigma-2 subunit; Sigma-3B-adaptin; Sigma3B-adaptin; Sigma-adaptin 3b 

Gene Name

 AP3S2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
149	EAQNRLEKSEGGLSA	ubiquitination	[1]
166	ARAVSAVKNINLPEI	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Cytoplasmic vesicle; Golgi apparatus; Membrane; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0030123; C:AP-3 adaptor complex; IDA:FlyBase.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; TAS:ProtInc.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0008089; P:anterograde axon cargo transport; ISS:UniProtKB.
 GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
 GO:0006886; P:intracellular protein transport; TAS:ProtInc. 

Interpro

 IPR016635; AP_complex_ssu.
 IPR022775; AP_mu_sigma_su.
 IPR027155; APS3.
 IPR000804; Clathrin_sm-chain_CS.
 IPR011012; Longin-like_dom. 

Pfam

 PF01217; Clat_adaptor_s 

SMART

  

PROSITE

 PS00989; CLAT_ADAPTOR_S 

PRINTS