UniProt Accession

 ATG5_MOUSE; Q99J83 

Genbank Protein ID

 AB048349; AK028315; BC002166 

Genbank Nucleotide ID

 BAB33383.1; BAC25874.1; AAH02166.1 

Protein Name

 Autophagy protein 5 

Protein Synonyms/Alias

 APG5-like 

Gene Name

 Atg5 

Gene Synonyms/Alias

 Apg5l 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
138	EADALKHKSQVINEM	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. 

Sequence Annotation

 CROSSLNK 130 130 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Autophagy; Complete proteome; Cytoplasm; Isopeptide bond; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 275 AA 

Protein Sequence

Gene Ontology

 GO:0005776; C:autophagic vacuole; IDA:MGI.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0034045; C:pre-autophagosomal structure membrane; IDA:UniProtKB.
 GO:0000045; P:autophagic vacuole assembly; IMP:UniProtKB.
 GO:0001974; P:blood vessel remodeling; IMP:MGI.
 GO:0060047; P:heart contraction; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0031397; P:negative regulation of protein ubiquitination; IMP:MGI.
 GO:0048840; P:otolith development; IMP:MGI.
 GO:0043687; P:post-translational protein modification; IDA:UniProtKB.
 GO:0002739; P:regulation of cytokine secretion involved in immune response; IMP:MGI.
 GO:0042493; P:response to drug; IMP:MGI.
 GO:0009620; P:response to fungus; IMP:MGI.
 GO:0042311; P:vasodilation; IMP:MGI.
 GO:0055015; P:ventricular cardiac muscle cell development; IMP:MGI. 

Interpro

 IPR007239; Atg5. 

Pfam

 PF04106; APG5 

SMART

  

PROSITE

  

PRINTS