CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039617
UniProt Accession
Genbank Protein ID
 U47924 
Genbank Nucleotide ID
  
Protein Name
 Tyrosine-protein phosphatase non-receptor type 6 
Protein Synonyms/Alias
  
Gene Name
 PTPN6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
19LDAETLLKGRGVHGSubiquitination[1, 2, 3]
34FLARPSRKNQGDFSLubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 60 AA 
Protein Sequence
MVRWFHRDLS GLDAETLLKG RGVHGSFLAR PSRKNQGDFS LSVRTQGISM TCMEGRSLRL 60 
Gene Ontology
  
Interpro
 IPR000980; SH2. 
Pfam
 PF00017; SH2 
SMART
 SM00252; SH2 
PROSITE
 PS50001; SH2 
PRINTS
 PR00401; SH2DOMAIN.