UniProt Accession

 SPB6_HUMAN; P35237; B2RBA8; Q59F97; Q5TD06; Q7Z2Y7; Q96J44; Q9UDI7 

Genbank Protein ID

 Z22658; S69272; AK314578; BX538343; AL133351; CH471087; BC001394; BC098564; AB209563 

Genbank Nucleotide ID

 CAA80373.1; AAB30320.1; BAG37155.1; CAD98106.1; CAI23292.1; EAW55097.1; AAH01394.1; AAH98564.1; BAD92800.1 

Protein Name

 Serpin B6 

Protein Synonyms/Alias

 Cytoplasmic antiproteinase; CAP; Peptidase inhibitor 6; PI-6; Placental thrombin inhibitor 

Gene Name

 SERPINB6 

Gene Synonyms/Alias

 PI6; PTI 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
98	ANRLFGEKSCDFLSS	ubiquitination	[1]
129	DFISAVEKSRKHINT	ubiquitination	[1, 2]
179	NWDEQFDKENTEERL	ubiquitination	[2, 3]
252	EKELTYEKFVEWTRL	ubiquitination	[4]
314	QTDLSLSKVVHKSFV	ubiquitination	[4]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Deafness; Direct protein sequencing; Non-syndromic deafness; Polymorphism; Protease inhibitor; Reference proteome; Serine protease inhibitor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 376 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005829; C:cytosol; TAS:ProtInc.
 GO:0043234; C:protein complex; IDA:BHF-UCL.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:BHF-UCL.
 GO:0030162; P:regulation of proteolysis; IBA:RefGenome. 

Interpro

 IPR023795; Protease_inhib_I4_serpin_CS.
 IPR023796; Serpin_dom.
 IPR000215; Serpin_fam. 

Pfam

 PF00079; Serpin 

SMART

 SM00093; SERPIN 

PROSITE

 PS00284; SERPIN 

PRINTS